Estimation of postmortem interval through albumin in CSF by simple dye binding method

Parmar, Ankita K.; Menon, Shobhana K.

doi:10.1016/j.scijus.2015.07.005

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…Using bromocresol green dye-binding method, Parmar et al [52] studied albumin concentration in cisternal fluid samples at different time intervals. He found a significant and linear decrease in albumin levels, but only between 24-72 h postmortem.…”

Section: Albuminmentioning

confidence: 99%

“…However, only a few studies have included corpses stored at ambient temperature before CSF collection [31,52]. This may be partly due to ethical concerns that this methodology could raise in case of bodies left at room temperature for a long time.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…CSF has been considered as a suitable fluid compartment to investigate early postmortem chemical changes, as concentration gradients in this fluid are still effective inthe first few hours after death[6]. The exploration of some biomarkers may even remain relevant for a few days after death, as their concentrations have been found to change in CSF longer than 72 h post-mortem[5,36,38,50,52].…”

mentioning

confidence: 99%

“…Criteria used for selecting participants greatly differ from one study to another, which makes inter-comparison of results obtained for the same biomarker difficult.For example, some studies have included patients with CNS diseases or trauma[32,46,50] while others have not[3,13,20,52]. This may greatly affect the results as the post-mortem levels of intracellular biomarkers in the CSF from patients with CNS disorders (such as neurodegenerative disease, stroke or infection) or traumatic brain injury may be subject to an increase due to substantial brain cell death.…”

mentioning

confidence: 99%

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Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Peyron

Lehmann

Delaby

et al. 2019

Critical Reviews in Clinical Laboratory Sciences

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Biochemical markers of time since death in cerebrospinal fluid: a first step towards "Forensomics" The accurate estimation of the time of death is a challenge in forensic medicine, as the methods routinely used to assess the post-mortem interval (PMI) are far from being precise. Over the past decades, biochemical methods have been implemented on post-mortem samples to improve the precision of PMI estimation. Studies have focussed on the biochemical profiles of closed compartment body fluids, as they are preserved longer than blood after death and are thus subject to confined post-mortem chemical changes. Cerebrospinal fluid (CSF) has been considered a suitable fluid to investigate these changes, as it is found in large amounts and is easy to sample. Moreover, the main molecules found in CSF have known reference values in living subjects, unlike most other body fluids. In this literature review, we focus on the panel of biomarkers that have been studied in CSF based on their potential of offering information on the time of death. The interest of these biomarkers in casework and the research perspectives in this field are discussed. Integrating data from different methods, including biochemistry, for better estimation of the time of death would represent a step forward in the forensic field, paving the way for an innovative approach that we suggest to call "Forensomics".

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Section: Albuminmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Peyron

Lehmann

Delaby

et al. 2019

Critical Reviews in Clinical Laboratory Sciences

View full text Add to dashboard Cite

show abstract

“…Chen, Inamori-Kawamoto, Michiue, Ikeda, Ishikawa& Maeda, H. (2015), Girela, Villanueva, Irigoyen, Girela, Hernández-Cueto & Peinado (2008), Parmar & Menon (2015), Prieto-Bonete, PerezCarceles, & Luna (2015) considered that post-mortem interval (PMI) estimation had been, and remained, one of the main issues of forensic practice. The time-since-death evaluation is usually based on an assessment of morphological changes in postmortem tissues and body organs.…”

Section: Introductionmentioning

confidence: 99%

Post-Mortem Interval Estimation by Cerebro-Spinal Fluid Films Polarization Images Optical Structure Changing

Garazdiuk

Bachynskіy

Wanchuliak

et al. 2016

CBUP

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A computational approach to estimate postmortem interval using postmortem computed tomography of multiple tissues based on animal experiments

Shen,

Zhong,

Wang

et al. 2023

Int J Legal Med

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Estimation of postmortem interval through albumin in CSF by simple dye binding method

Cited by 15 publications

References 16 publications

Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Biochemical markers of time since death in cerebrospinal fluid: A first step towards“Forensomics”

Post-Mortem Interval Estimation by Cerebro-Spinal Fluid Films Polarization Images Optical Structure Changing

A computational approach to estimate postmortem interval using postmortem computed tomography of multiple tissues based on animal experiments

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