Estimation of renal function in patients with liver cirrhosis: Impact of muscle mass and sex

Yoo, Jeong‐Ju; Kim, Sang Gyune; Kim, Young Seok; Lee, Bora; Lee, Min Hee; Jeong, Soung Won; Jang, Jae Young; Lee, Sae Hwan; Kim, Hong Soo; Kim, Young Don; Cheon, Gab Jin

doi:10.1016/j.jhep.2018.12.030

Cited by 77 publications

(114 citation statements)

References 35 publications

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“…Cr values in men were higher than those in women (Table ). Sex differences for Cr are dependent on muscle volume . Testosterone is a male sex hormone, and contributes to the strength and synthesis of muscle .…”

Section: Discussionmentioning

confidence: 99%

“…Muscle volume and strength evaluations require the use of instruments, whereas CBMMs require only blood samples and BW measurements. Because assessing renal function in liver disease requires the measurements of serum Cr and CysC, determining CBMM is a reasonable and simple index . Additionally, although SIs are useful for evaluating muscle mass, they are weak indices for GS and sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

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Calculated body muscle mass as a useful screening marker for low skeletal muscle mass and sarcopenia in chronic liver disease

Ichikawa

Miyaaki

Miuma

et al. 2020

Hepatology Research

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Aim Sarcopenia is a harmful condition in patients with chronic liver disease. However, the evaluation of body muscle mass requires expensive instrumentation. The sarcopenia index (SI): (creatinine / cystatin C × 100) has been reported to correlate with muscle volume. A calculated body muscle mass (CBMM) using creatinine, cystatin C, and bodyweight also correlates with muscle mass. We evaluated the applicability of using SIs and CBMMs as screening methods for sarcopenia. Methods Patients (n = 303) with liver damage were evaluated for creatinine, cystatin C, and grip strength (GS). All patients were evaluated using cross‐sectional computed tomography images of the third lumbar vertebrae to determine their skeletal muscle (SM) mass. CBMMs and SIs were compared with SMs, GSs, and sarcopenia. Results Correlation coefficients (R) between SMI (SM / height2 [m2]) and CBMM, and between GS and CBMM were 0.643 and 0.723, respectively. Factors contributing to low GSs; low SM indices; and sarcopenia were age and SM; sex, age, GS, SI, and CBMM indices; and sex, bodyweight, and CBMM, respectively, in the multivariate logistic analyses. Receiver operating characteristic curve analysis between sarcopenia and CBMM showed an area under the receiver operating characteristic curve of 0.78504 in women and 0.86067 in men. Cut‐off CBMM values for sarcopenia were 27.903 (sensitivity 0.73958) in women and 39.731 (sensitivity 0.7941) in men. Conclusions CBMMs and SIs are simple and minimally invasive screening methods in which low levels are indicative of sarcopenia in patients with liver disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Calculated body muscle mass as a useful screening marker for low skeletal muscle mass and sarcopenia in chronic liver disease

Ichikawa

Miyaaki

Miuma

et al. 2020

Hepatology Research

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“…The study by Jeong-Ju Yoo et al demonstrated that female sex, impaired liver function, and decreased muscle mass in males are independent risk factors of overestimation of renal function. Cystatin-C based eGFR is recommended to trace the renal function in these patients, especially in male patients with cirrhosis and sarcopenia [11]. In addition, Ryosuke Sugimoto et al also reported that HCV patients who undergone DAA treatment may induce the increase of muscle mass after treatment [12].…”

Section: Plos Onementioning

confidence: 99%

Serial changes of renal function after directly acting antivirals treatment for chronic hepatitis C: A 1-year follow-up study after treatment

et al. 2020

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BackgroundOur preliminary data showed a slight decrease of estimated glomerular filtration rate (eGFR) after direct-acting antivirals (DAAs) treatment in chronic hepatitis C (CHC). However, long-term outcome of renal evolution after DAAs has not been well documented. AimTo assess the renal function under DAAs treatment in CHC patients of an Asian population at 6 months and 1 year after complete treatment. MethodsA cohort of 1536 CHC patients who received therapies with DAAs were analyzed. Serial eGFR levels at 24 weeks after treatment (SVR 24 ) and 48 weeks after treatment (SVR 48 ) were evaluated. We compared eGFR at baseline, SVR 12 , SVR 24 and SVR 48 , and defined renal function deterioration as decrease of eGFR >25% from baseline to SVR 24 and SVR 48 .

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“…Conversely, serum cystatin C (CysC)-based estimated GFR (CysCGFR) shows improved correlation with measured GFR and improved predictability for overall survival and incidence of acute kidney injury compared with CrGFR (2-4). CysC appears to be more sensitive than Cr for patients with declining GFR in chronic liver disease (3)(4)(5). However, CysC positively correlates with body mass index (BMI) and is more strongly correlated with waist circumference and inflammation (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease

et al. 2020

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Serum creatinine (Cr)-based glomerular filtration rate (CrGFR) is overestimated in liver disease. The present study evaluated whether the difference in CrGFR and cystatin C (CysC) GFR (dGFR) is significant in liver disease. The Cr-to-CysC ratio and sarcopenia index (SI) have been reported to correlate with muscle volume. An estimated total body muscle mass with Cr, CysC and calculated body muscle mass (CBMM) has also been reported to correlate with muscle mass. The applicability of dGFR, SI and CBMM for liver disease were evaluated. A total of 313 patients with liver damage were evaluated for Child-Pugh score, albumin-bilirubin (ALBI) score, model for end-stage liver disease, fibrosis-4, Cr, CysC, Cr-based estimated GFR (CreGFR), CysCGFR and grip strength. Of the 313 patients, 199 were evaluated using cross-sectional computed tomography (CT) of the third lumbar vertebra to determine the skeletal muscle (SM) mass. dGFR, CBMM and SI were compared to liver damage, muscle strength and muscle mass. In the 313 patients, dGFR was correlated with age, ALBI and grip strength; CBMM was correlated with body mass index (BMI) and grip strength; and SI was correlated with BMI and grip strength. In patients evaluated with CT, the correlation coefficients for CBMM and SI with SM were 0.804 and 0.293, respectively. Thus, CBMM and SI were associated with sarcopenia. The relationship between dGFR and ALBI does not differ with different grades of CrGFR-based chronic kidney disease (CKD). dGFR is a marker of liver damage and muscle strength regardless of CKD. CBMM and SI are markers for sarcopenia in liver disease.

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Estimation of renal function in patients with liver cirrhosis: Impact of muscle mass and sex

Cited by 77 publications

References 35 publications

Calculated body muscle mass as a useful screening marker for low skeletal muscle mass and sarcopenia in chronic liver disease

Calculated body muscle mass as a useful screening marker for low skeletal muscle mass and sarcopenia in chronic liver disease

Serial changes of renal function after directly acting antivirals treatment for chronic hepatitis C: A 1-year follow-up study after treatment

Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease

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