Estimation of Serum Osteocalcin Levels in Osteoporotic Postmenopausal Iraqi Women with Type 2 Diabetes Mellitus

Abstract

Background: Osteoporosis (OP) is a systemic disease characterized by low bone mass and micro architectural deterioration of bone tissue, resulting in an increased risk of fractures and has touched rampant proportions. Osteocalcin, one of the osteoblast-specific proteins, showed that its functions as a hormone improves glucose metabolism and reduces fat mass ratio. This study is aimed to estimate the osteocalcin and glucose level in blood serum of osteoporotic postmenopausal Women with and without Type 2 Diabetes.Materials and methods: 60 postmenopausal women with osteoporosis divided into two groups depending on with or without T2DM, 30 patients for each. Serum samples of 30 healthy postmenopausal women were collected as control group. Osteocalcin was measured by ELISA method using a kit of (CUSABIO. China). Glucose was determined by spectrophotometric method. Results: Mean serum osteocalcin in postmenopausal osteoporotic women without Type II Diabetes is higher than control group and the group with T2DM (p ? 0.001). Conclusion: Bone formation marker increases at postmenopausal osteoporosis women; Hyperglycemia also induces osteoblast function and reduces of production osteocalcin at T2DM.

The Influence of Obesity and IL-6 on Infertile Iraqi Women with COVID-19 Complications

“…Obesity is one of the most prevalent public health issues in the world today, which has developed like an epidemic across the globe. The world health organization (WHO) predicts that one in five persons globally will be obese by 2025, although the fact that the link between obesity and increased risk of mortality and morbidity has been known for more than 20 years [1][2][3] .…”