Stress is any psycho-emotional tension experienced by nursing professionals during the coronavirus pandemic, therefore, the objective of the investigation is to determine the level of stress in nursing professionals in a hospital center during the COVID-19 pandemic. It is a quantitative, descriptive, cross-sectional and non-experimental study, with a population of 127 nursing professionals, who completed a sociodemographic data questionnaire and the nursing stress scale. In their results, 12.6% (n=16) of nurses have high stress, 40.9% (n=52) medium stress and 46.5% (n=59) low stress. In conclusion, programs aimed at mental health, training in resilient skills and coping strategies for stress must be created.