Estrogen and Progesterone Receptor Expression in Endometrial Polyps

Mittal, Khush; Schwartz, Lisa Barrie; Goswami, Sunanda; Demopoulos, Rita I.

doi:10.1097/00004347-199610000-00007

Cited by 110 publications

(80 citation statements)

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“…Ek olarak endometrial poliplerin menarş öncesi görülmemesi ve sıklıkla eşlik eden bir hiperplazi bulunması hormonal faktörlerin etkili olduğu görüşünü desteklemektedir 12 . Sant' Ana de Almeida ve ark.…”

Section: Discussionunclassified

The Relationship Between Endometrial Polyps, Obesity, the Incidence of Diabetes and Hypertension in Women Who Admitted with Abnormal Uterin Bleeding in Reproductive Ages

Yücel¹,

Seçkin²,

Özköse³

et al. 2017

Kafkas J Med Sci

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Aim: To investigate whether endometrial polyps are associated with obesity and incidence of diabetes mellitus or hypertension in women who admitted with abnormal uterin bleeding in reproductive ages. Material and Method (30,1±2,94), kontrol grubu (28,2±1,92) ile karşılaştırıldığında istatistiksel olarak anlamlı yüksekti (p <0,001). Diyabet ve hipertansiyon sıklığı yine endometrial polip grubunda (%8,33 ve %6,67) kontrol grubuna oranla (%3,44 ve %2,19)

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Section: Discussionunclassified

The Relationship Between Endometrial Polyps, Obesity, the Incidence of Diabetes and Hypertension in Women Who Admitted with Abnormal Uterin Bleeding in Reproductive Ages

Yücel¹,

Seçkin²,

Özköse³

et al. 2017

Kafkas J Med Sci

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“…Endometrial polyps may be relatively insensitive to cyclic hormonal changes by the facts that they are not encountered prior to menarche, some small polyps spontaneously regress over time and HRT, late menopause and obesity increased the occurrence of endometrial polyps. 6,21,23 Similarly an abnormal response to certain hormonal stimuli may be involved in the process of cervical polyps. In this study, control group were chosen with the same menopausal status; and cases receiving HRT, birth control pills and Tamoxiphene (Nolvadex, AstraZeneca, UK) were excluded.…”

Section: Discussionmentioning

confidence: 99%

Are Obesity, Diabetes, and Hypertension Risk Factors for Cervical Polyps?

Uçar¹,

Uçar²,

İlhan³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

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226ervical polyps are common benign neoplasms of the cervix in adult women.1 They are believed to develop as a result of focal hyperplasia. They usually develop in multiparous women during the fifth Are Obesity, Diabetes, and Hypertension Risk Factors for Cervical Polyps?A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate whether diabetes, hypertension, and obesity can be considered risk factors for cervical polyps. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The hospital-based case-control study was carried out. We retrospectively reviewed the records of 307 consecutive patients with cervical polyps. A control group consisting of 3 women per case-matched by the same age, same parity, same menopausal status and the same presenting symptoms. These groups were compared with respect of diabetes, hypertension and obesity prevalence. R Re es su ul lt ts s: : The study included a total of 212 patients eligible for analysis in cervical polyp group, and a matched control group consisting of 636 women without cervical polyp. Women with cervical polyp had higher body mass index than the controls, but the difference was not statistically significant (p=0.72). The prevalence of obesity was significantly higher in the cervical polyp group than the controls (p=0.016). A statistically significant correlation was found between obesity and cervical polyps (OR: 1.351, CI: 1.062-1,718). There was no significant difference between the groups with respect to the prevalence of diabetes (p=0.795) and hypertension (p=0.703). C Co on nc cl lu us si io on n: : Obesity appears to be a risk factor for cervical polyps. Obese women should receive special attention for potential coexistence of cervical polyps as part of their gynecological evaluation. This study supports the importance of weight management for the preventive plan of cervical polyps.K Ke ey y W Wo or rd ds s: : Cervix uteri; polyps; diabetes mellitus; hypertension; obesity Ö ÖZ ZE ET T A Am ma aç ç: : Diyabet, hipertansiyon ve obezitenin servikal polipler için risk faktörü olup olmadığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Hastane tabanlı vaka-kontrol çalışması oluşturuldu. 307 ardışık servikal polip hastasının kayıtları retrospektif olarak değerlendirildi. Her servikal polip hastası için, aynı yaş, aynı parite, aynı menopozal durumda ve aynı başvuru şikayeti ile gelen 3 kontrol hastası belirlendi. Gruplar hipertansiyon, diyabet ve obezite prevalansı açısından karşılaştırıldı. B Bu ul lg gu ul la ar r: : Çalışma kriterlerine uygun servikal polibi olan 212 hasta vaka grubuna ve servikal polibi olmayan eşleştirilmiş 636 hasta kontrol grubuna dahil edildi. Servikal polip hastalarının beden kitle indeksi, kontrol grubundan daha fazlaydı, ancak bu fark istatistiksel anlamlı değildi (p=0,72). Obezite prevalansı servikal polip grubunda, kontrol grubundan istatistiksel olarak anlamlı düzeyde yüksek bulundu (p=0,016). Obezite ve servikal polipler arasında istatistiksel anlamlı düzeyde korelasyon saptandı (OR: 1,351, ...

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“…In premenopausal women, a decrease in oestrogen and progesterone receptors within polyp stromal cells, although not the glandular component, has been found, which may make polyps less sensitive to cyclic hormonal changes. [6][7][8] Others have pointed to increased cell longevity, as a result of inhibition of apoptosis 7,9 and biomarkers for altered gene expression have been documented within uterine polyps.…”

Section: Aetiology Of Uterine Polypsmentioning

confidence: 99%

A randomised controlled trial of Outpatient versus inpatient Polyp Treatment (OPT) for abnormal uterine bleeding

Clark

Middleton

Cooper

et al. 2015

Health Technol Assess

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BackgroundUterine polyps cause abnormal bleeding in women and conventional practice is to remove them in hospital under general anaesthetic. Advances in technology make it possible to perform polypectomy in an outpatient setting, yet evidence of effectiveness is limited.ObjectivesTo test the hypothesis that in women with abnormal uterine bleeding (AUB) associated with benign uterine polyp(s), outpatient polyp treatment achieved as good, or no more than 25% worse, alleviation of bleeding symptoms at 6 months compared with standard inpatient treatment. The hypothesis that response to uterine polyp treatment differed according to the pattern of AUB, menopausal status and longer-term follow-up was tested. The cost-effectiveness and acceptability of outpatient polypectomy was examined.DesignA multicentre, non-inferiority, randomised controlled trial, incorporating a cost-effectiveness analysis and supplemented by a parallel patient preference study. Patient acceptability was evaluated by interview in a qualitative study.SettingOutpatient hysteroscopy clinics and inpatient gynaecology departments within UK NHS hospitals.ParticipantsWomen with AUB – defined as heavy menstrual bleeding (formerly known as menorrhagia) (HMB), intermenstrual bleeding or postmenopausal bleeding – and hysteroscopically diagnosed uterine polyps.InterventionsWe randomly assigned 507 women, using a minimisation algorithm, to outpatient polypectomy compared with conventional inpatient polypectomy as a day case in hospital under general anaesthesia.Main outcome measuresThe primary outcome was successful treatment at 6 months, determined by the woman’s assessment of her bleeding. Secondary outcomes included quality of life, procedure feasibility, acceptability and cost per quality-adjusted life-year (QALY) gained.ResultsAt 6 months, 73% (166/228) of women who underwent outpatient polypectomy were successfully treated compared with 80% (168/211) following inpatient polypectomy [relative risk (RR) 0.91, 95% confidence interval (CI) 0.82 to 1.02]. The lower end of the CIs showed that outpatient polypectomy was at most 18% worse, in relative terms, than inpatient treatment, within the 25% margin of non-inferiority set at the outset of the study. By 1 and 2 years the corresponding proportions were similar producing RRs close to unity. There was no evidence that the treatment effect differed according to any of the predefined subgroups when treatments by variable interaction parameters were examined. Failure to completely remove polyps was higher (19% vs. 7%; RR 2.5, 95% CI 1.5 to 4.1) with outpatient polypectomy. Procedure acceptability was reduced with outpatient compared with inpatient polyp treatment (83% vs. 92%; RR 0.90, 95% CI 0.84 to 0.97). There were no significant differences in quality of life. The incremental cost-effectiveness ratios at 6 and 12 months for inpatient treatment were £1,099,167 and £668,800 per additional QALY, respectively.ConclusionsWhen treating women with AUB associated with uterine polyps, outpatient polypectomy was non-inferior to inpatient polypectomy at 6 and 12 months, and relatively cost-effective. However, patients need to be aware that failure to remove a polyp is more likely with outpatient polypectomy and procedure acceptability lower.Trial registrationCurrent Controlled Trials ISRCTN 65868569.FundingThis project was funded by the NIHR Health Technology Assessment programme and will be published in full inHealth Technology Assessment; Vol. 19, No. 61. See the NIHR Journals Library website for further project information.

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Estrogen and Progesterone Receptor Expression in Endometrial Polyps

Cited by 110 publications

References 0 publications

The Relationship Between Endometrial Polyps, Obesity, the Incidence of Diabetes and Hypertension in Women Who Admitted with Abnormal Uterin Bleeding in Reproductive Ages

The Relationship Between Endometrial Polyps, Obesity, the Incidence of Diabetes and Hypertension in Women Who Admitted with Abnormal Uterin Bleeding in Reproductive Ages

Are Obesity, Diabetes, and Hypertension Risk Factors for Cervical Polyps?

A randomised controlled trial of Outpatient versus inpatient Polyp Treatment (OPT) for abnormal uterine bleeding

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