Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio)

Kishida, Michiko; McLellan, Megan E.; Miranda, Jason A.; Callard, Gloria V.

doi:10.1016/s1096-4959(01)00319-0

Cited by 184 publications

(78 citation statements)

References 16 publications

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“…In Fundulus heteroclitus, 0.01 and 1 µmol/L E 2 in the maintaining medium induces death of embryos and fry, malformations, sex reversal, and incomplete ossification of vertebrae and cranial bones, which would result in shorter body and head lengths and in malformed vertebrae, leading to a hunchback condition (Urushitani et al 2002). Kishida et al (2001) reported that the treatment of zebrafish embryos (Danio rerio) with 0.1-10 µmol/L E 2 between 2 and 72 hr postfertilization provoked dose-response effects on mortality and hatching and induced the "curved tail down" phenotype characteristically similar to mutants with defects in the central nervous system. According to the authors, these effects could be mediated by the P450 aromatase enzyme (Kishida et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Kishida et al (2001) reported that the treatment of zebrafish embryos (Danio rerio) with 0.1-10 µmol/L E 2 between 2 and 72 hr postfertilization provoked dose-response effects on mortality and hatching and induced the "curved tail down" phenotype characteristically similar to mutants with defects in the central nervous system. According to the authors, these effects could be mediated by the P450 aromatase enzyme (Kishida et al 2001). The acute toxic effect of E 2 in Bufo arenarum embryos reported in this study occurs at similar concentrations as in zebrafish.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Estradiol uptake, toxicity, metabolism, and adverse effects on cadmium-treated amphibian embryos.

Fridman

Corró

Herkovits

2004

Environ Health Perspect

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The exposure of Bufo arenarum embryos to 25 µmol/L 17β-estradiol (E 2 ) resulted in 100% lethality within 48 hr, whereas 10 µmol//L E 2 was the no observed effect concentration value for shortterm chronic (7 days) exposure. The toxicity profile curves show that lethal effects were proportional to the E 2 concentration and the time of exposure. The E 2 uptake resulted in 20.1 ng E 2 /mg embryo at 8 hr posttreatment, but 67.3% of this value was achieved during the first 30 min of incubation with this estrogen. Regarding metabolism, the embryos synthesize estrone (E 1 ) from E 2 by means of 17β-hydroxysteroid dehydrogenase. Simultaneous treatments of Bufo arenarum embryos with 1 mg/L Cd 2+ and 0.1, 1, or 10 µmol/L E 2 enhanced the lethality exerted by cadmium in 76.7, 80, and 83.3% of embryos, respectively. The results indicate that estrogenic endocrine disruptors could have an adverse effect on amphibian embryos and enhance the toxic effect of Cd on amphibian embryos. This study points to the possibility of using the AMPHITOX test as a screening method for potential endocrine disruption as well as the combined effects of chemical mixtures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Estradiol uptake, toxicity, metabolism, and adverse effects on cadmium-treated amphibian embryos.

Fridman

Corró

Herkovits

2004

Environ Health Perspect

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“…3.2.10.3 Fish: Kishida et al (2001), supported by the National Science Foundation and U.S. EPA, included bisphenol A in a study to test the utility of changes in CYP450 aromatase mRNA expression as a marker of xenoestrogen effects in the CNS of zebrafish (Danio rerio). Fish embryos were incubated in solutions containing bisphenol A [purity not indicated] at 0 (DMSO vehicle), 0.01, 0.1, or 10 mM [0, 2.3, 23, or 228 lg/L] from 2-48 hr post-fertilization [culture ware not discussed].…”

Section: Utility (Adequacy) For Cerhr Evaluation Processmentioning

confidence: 99%

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

404

304

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“…Estrogen synthesized in the brain by the action of P450 aromatase is known to have organizing efects on the developing central nervous system. In ish, estrogen increases the predominant brain isoform (P450aromB), implying that xenoestrogens like BPA could act as neurodevelopmental toxicants by altering the expression of P450aromB [80].…”

Section: Bisphenol a Exposure And Health Risksmentioning

confidence: 99%

Bisphenol A: Understanding Its Health Effects from the Studies Performed on Model Organisms

Ghosh¹,

Roy²,

Begum³

et al. 2017

Bisphenol a Exposure and Health Risks

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Bisphenol A [4,4′-(propane-2,2-diyl)diphenol] (abbreviated as BPA) is a synthetic xenoestrogenic chemical and endocrine disruptor. It is a most common plasticizer that is used widely to produce epoxy resin and polycarbonate plastics, enters the living system through food and water contamination and generates health hazards. Researches are being conducted to explore the adversity that BPA exerts in living body, and for this reason, model organisms are of scientiic choice. Rodents, zebraish, Drosophila, nematodes, crustaceans and echinoderms are being used for monitoring the efect of BPA on their life history traits, nervous system, endocrine system, reproductive systems, behaviour, etc., which could help us to anticipate what kind of challenges BPA is puting in human life. This systematic review is focused on the latest research trend on BPA toxicity on diferent model organisms.

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Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio)

Cited by 184 publications

References 16 publications

Estradiol uptake, toxicity, metabolism, and adverse effects on cadmium-treated amphibian embryos.

Estradiol uptake, toxicity, metabolism, and adverse effects on cadmium-treated amphibian embryos.

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Bisphenol A: Understanding Its Health Effects from the Studies Performed on Model Organisms

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