Estrogen biosynthesis: metabolism of [16,16,19-2H3][19-3H] 19-oxoandrost-4-ene-3,17-dione by a placental microsomal preparation

Current evidence is consistent with the view that biosynthesis of estrogens b y human microsomal placental aromatase proceeds through several different pathways. One of the proposed mechanisms of aromatization of androgens involves the intermediacy of 2phydroxy-19-oxoandrost-4-ene-3,17dione 1 a. It is shown that incubation of 2P[180H]-1 b with placental aromatase gave HCq800Hwhich differs from previous observations. The incorporation of isotopic oxygen in the formic acid is consistent with the view that one of the alternative routes of estrogen elaboration may involve a 2p,19dioxygenated androgen.

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Biosynthesis of estrogens. Estr-5(10)-ene-3,17-dione: isolation, metabolism and mechanistic implications

Dharmaratne¹,

Kilgore²,

Roitman³

et al. 1993

J. Chem. Soc., Perkin Trans. 1

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Estrogen biosynthesis: metabolism of [16,16,19-2H3][19-3H] 19-oxoandrost-4-ene-3,17-dione by a placental microsomal preparation

Cited by 3 publications

References 2 publications

Functional ovarian and placental isoforms of porcine aromatase

Functional ovarian and placental isoforms of porcine aromatase

Estrogen biosynthesis: 2β-hydroxy-19-oxoandrost-4-ene-3,17-dione revisited

Biosynthesis of estrogens. Estr-5(10)-ene-3,17-dione: isolation, metabolism and mechanistic implications

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