2022
DOI: 10.1101/2022.10.07.511340
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Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs

Abstract: Estrogen receptor α (ER) mutations occur in up to 30% of metastatic ER-positive breast cancers. Recent data has shown that ER mutations impact the expression of thousands of genes not typically regulated by wildtype ER. While the majority of these altered genes can be explained by constant activity of mutant ER or genomic changes such as altered ER binding and chromatin accessibility, as much as 33% remain unexplained, indicating the potential for post-transcriptional effects. Here we explored the role of micr… Show more

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