2002
DOI: 10.1677/erc.0.0090001
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Estrogen receptor beta in breast cancer.

Abstract: Estrogen is essential for normal growth and differentiation in the mammary gland. It also supports growth of approximately 50% of primary breast cancers. For this reason, removal of estrogen or blocking of its action with the anti-estrogen, tamoxifen, is the main treatment for estrogen receptor alpha (ERα)-positive tumors. In 1996, when oncologists became aware of a second ER, ERβ, there was some doubt as to whether this receptor would be of importance in breast cancer because the clinical consensus was that r… Show more

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Cited by 218 publications
(160 citation statements)
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“…In support of this, abnormal epithelial growth, expression of the proliferation marker Ki67, and age-related cystic breast disease were observed in one model of BERKO mice [57,69]. However, these results have not been replicated in other BERKO mouse models, and normal mammary gland histology was observed in a recently developed model of old BERKO females [41].…”
Section: Potential Role Of Erα/erβ Heterodimers In Biological Responsmentioning
confidence: 98%
“…In support of this, abnormal epithelial growth, expression of the proliferation marker Ki67, and age-related cystic breast disease were observed in one model of BERKO mice [57,69]. However, these results have not been replicated in other BERKO mouse models, and normal mammary gland histology was observed in a recently developed model of old BERKO females [41].…”
Section: Potential Role Of Erα/erβ Heterodimers In Biological Responsmentioning
confidence: 98%
“…The second receptor, ER, has likewise been detected in human breast cancers and may also contribute to hormonal sensitivity and resistance [47][48][49]. The clinical assay of this receptor has not been performed in large series.…”
Section: Expression Of Estrogen Receptor mentioning
confidence: 99%
“…The initial studies by reverse transcription PCR analysis concerning the prognostic significance of ER were controversial. However, several studies indicated that the ER RNA level was decreased in invasive breast cancer tissues compared with the adjacent normal mammary gland [49]. The mechanism and role of the decrease in ER in carcinogenesis are unknown.…”
Section: Expression Of Estrogen Receptor mentioning
confidence: 99%
“…However, only about 50% of ERa-expressing tumors respond well to hormonal therapy. ERb is expressed at high concentration in normal human mammary gland tissue and expression is lost or decreased in breast cancer (Palmieri et al, 2002;Esslimani-Sahla et al, 2005). When it is reintroduced into breast cancer cells, ERb is antiproliferative (Paruthiyil et al, 2004;Strom et al, 2004;Murphy et al, 2005;Hartman et al, 2006).…”
Section: Introductionmentioning
confidence: 99%