Estrogen Regulates the Expression and Function of lncRNA-H19 in Ectopic Endometrium

Liu, Songping; Tang, Xiaoyan; Li, Qinmei; Shao, Wang

doi:10.2147/ijwh.s365943

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Banz et al, using the microarray technique, showed differences in gene expression in endometrial carcinoma tissue and endometroid carcinoma arising in the scopeof endometriosis [50]. H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells [18]. In a study by Liu et al lncRNA H19 showed the greatest upregulation in the ectopic and eutopic endometrium [51].…”

Section: Discussionmentioning

confidence: 99%

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Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Smolarz,

Szaflik,

Romanowicz

et al. 2024

IJMS

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The coordinated action of VEGF, IGF1/2 and H19 factors influences the development of endometriosis. The aim of this study was to analyze the expression level of these genes in patients with endometriosis. The study group consisted of 100 patients who were diagnosed with endometriosis on laparoscopic and pathological examination. The control group consisted of 100 patients who were found to be free of endometriosis during the surgical procedure and whose eutopic endometrium wasnormal on histopathological examination. These patients were operated on for uterine fibroids. Gene expression was determined by RT-PCR. The expression of the VEGF gene was significantly higher in the samples classified as clinical stage 1–2 compared to the control material (p < 0.05). There was also a statistically significant difference between the samples studied at clinical stages 1–2 and 3–4 (p < 0.01). The expression of the VEGF gene in the group classified as 1–2 was significantly higher. IGF1 gene expression was significantly lower both in the group of samples classified as clinical stages 1–2 and 3–4 compared to the control group (p < 0.05 in both cases). The expression of the H19 gene was significantly lower in the group of samples classified as clinical stage 3–4 compared to the control group (p < 0.01). The reported studies suggest significant roles of VEGF, IGF and H19 expression in the pathogenesis of endometriosis.

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Section: Discussionmentioning

confidence: 99%

“…17β-estradiol is known to play a role in regulating H19 expression and function in endometriosis patients. 17β-estradiol is therefore involved in the development of endometriosis by regulating H19 [18]. H19 regulates endometrial tissue proliferation by altering IGF signaling in endometriosis [19].…”

Section: Introductionmentioning

confidence: 99%

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Smolarz,

Szaflik,

Romanowicz

et al. 2024

IJMS

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show abstract

“…It has been observed that 17β-estradiol plays a role in regulating the expression pattern and function of H19 in patients with endometriosis. Based on these findings, it can be concluded that 17β-estradiol is involved in the development of endometriosis through the regulation of H19 [ 98 ]. According to a study by Sedigheh et al, the expression level of H19 was found to be significantly decreased in both ectopic and eutopic endometrial tissues compared to control tissues.…”

Section: Exploring the Significance Of Lncrna H19 In Gynecologic Canc...mentioning

confidence: 99%

The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers

Ghasemian,

Zehtabi,

Dari

et al. 2024

BMC Cancer

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Long non-coding RNA (lncRNA) H19 has gained significant recognition as a pivotal contributor to the initiation and advancement of gynecologic cancers, encompassing ovarian, endometrial, cervical, and breast cancers. H19 exhibits a complex array of mechanisms, demonstrating dualistic effects on tumorigenesis as it can function as both an oncogene and a tumor suppressor, contingent upon the specific context and type of cancer being investigated. In ovarian cancer, H19 promotes tumor growth, metastasis, and chemoresistance through modulation of key signaling pathways and interaction with microRNAs. Conversely, in endometrial cancer, H19 acts as a tumor suppressor by inhibiting proliferation, inducing apoptosis, and regulating epithelial-mesenchymal transition. Additionally, H19 has been implicated in cervical and breast cancers, where it influences cell proliferation, invasion, and immune evasion. Moreover, H19 has potential as a diagnostic and prognostic biomarker for gynecologic cancers, with its expression levels correlating with clinical parameters and patient outcomes. Understanding the functional roles of H19 in gynecologic cancers is crucial for the development of targeted therapeutic strategies and personalized treatment approaches. Further investigation into the intricate molecular mechanisms underlying H19’s involvement in gynecologic malignancies is warranted to fully unravel its therapeutic potential and clinical implications. This review aims to elucidate the functional roles of H19 in various gynecologic malignancies.

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“…Studies have shown that H19 expression is noticeably higher in the ectopic endometrium of patients with endometriosis than in the normal endometrium [ 31 ]. Alterations in the H19/miR-216a-5p/actin alpha 2 (ACTA2) pathway may be involved in H19-mediated invasion and migration of ectopic ESCs, which could be an underlying cause of fibrogenesis or fibrosis in patients with endometriosis [ 32 ].…”

Section: H19 and Endometriosismentioning

confidence: 99%

The role of long non-coding RNA H19 in infertility

et al. 2023

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Infertility is defined as the failure to conceive after at least one year of unprotected intercourse. Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 nucleotides but do not convert into proteins. LncRNAs, particularly lncRNA H19, have been linked to the emergence and progression of various diseases. This review focuses on the role of H19 in infertility caused by polycystic ovary syndrome, endometriosis, uterine fibroids, diminished ovarian reserve, male factor, and assisted reproductive technology-related pathology, highlighting the potential of H19 as a molecular target for the future treatment of infertility.

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Estrogen Regulates the Expression and Function of lncRNA-H19 in Ectopic Endometrium

Cited by 5 publications

References 32 publications

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers

The role of long non-coding RNA H19 in infertility

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