Estrogen-α and progesterone receptor expression in cystic endometrial hyperplasia and pyometra in the bitch

Bosschere, H. De; Ducatelle, Richard; Vermeirsch, H.; Simoens, Paul; Coryn, M.

doi:10.1016/s0378-4320(02)00013-1

Cited by 51 publications

(49 citation statements)

References 23 publications

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“…De Bosschere et al (2002) demonstrated in their study that cystic endometrial hyperplasiamucometra is associated with a higher score of the estrogen-α receptor and progesterone receptor in bitches in diestrus. In normal canines, P4 causes a down regulation of the estrogen-α receptor (Vermeirsch et al 1999).…”

Section: Introductionmentioning

confidence: 96%

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Gossler

Santos

Azevedo

et al. 2017

An. Acad. Bras. Ciênc.

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This study aimed to determine the histological features of the endometrium of bitches, as well as the cell proliferation at specific moments of diestrus, 10, 20, 30, 40, 50 and 60 days post ovulation, correlating the endometrial thickness with the uterine cell proliferation and the metabolic state (weight, blood glucose and plasma cholesterol) of the animals. Therefore, the right and left uterine horns of 26 clinically healthy bitches submitted to ovariohysterectomy were histologically analyzed 10, 20, 30, 40, 50 and 60 days post ovulation. The hematoxylin-eosin and AgNOR staining techniques were performed. All parameters were evaluated by ANOVA and post-hoc Tukey test (p<0.05). The correlation between endometrial thickness and uterine cell proliferation, weight, blood glucose and plasma cholesterol of animals was observed using the Pearson method (p<0.05). In the present study, it is concluded that endometrial thickness does not differ at any of the moments analyzed in diestrus. The endometrial thickness is not influenced by hormones, weight, blood glucose or serum cholesterol of bitches in this phase of the estrous cycle. However, there is greater cell proliferation in the endometrium at day 40 compared to day 60 post ovulation under the influence of the endocrine profile.

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Section: Introductionmentioning

confidence: 96%

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Gossler

Santos

Azevedo

et al. 2017

An. Acad. Bras. Ciênc.

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“…Ostrogens have a harmful impact on the function of the bone marrow, parenchymal organs and skin. Long-term administration of feeds contaminated with low doses of ZEN, a mycestrogen, can lead to dysfunctions of the uterus (Stopa et al 2014), in which permanent changes frequently accompany the spontaneous endometritis-pyometra complex (De Bosschere et al 2002b, Galabova--Kovacs et al 2004, Freeman et al 2013a.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical evaluation of apoptosis and proliferation in the mucous membrane of selected uterine regions in pre-pubertal bitches exposed to low doses of zearalenone

Stopa¹,

Babińska²,

Zielonka³

et al. 2016

Polish Journal of Veterinary Sciences

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Mycotoxins are toxic secondary metabolites produced by fungi. Those biologically active compounds occur naturally and they include zearalenone (ZEN), a mycotoxin that contaminates plant material, including the ingredients used in the production of commercial dog food. The influence of monotonic, low-dose and long-term exposure to ZEN on pre-pubertal bitches has not been fully explored to date. This paper describes a 42-day experiment performed on clinically healthy female dogs aged approximately 70 days, with estimated body weight of 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group (C) of 10 animals each. Group EI received 50 μg ZEN/kg (of body weight) per os, group EII received 75 μg ZEN/kg BW per os, and the control group was administered placebo. The bitches were ovariohysterectomized at the end of the experiment (at around 112 days of age), and selected sections of the uterine wall were subjected to immunohistochemical analyses (TUNEL and PCNA). A shift towards higher apoptotic (AI) and proliferative index (PI) was observed, in particular in group EI. Higher AI and PI values were noted in the epithelium of all uterine regions analysed and in the uterine glands in the uterine horn proximal to the body of the uterus.

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“…Muitos são os estudos relacionados às concentrações séricas de tais hormônios, bem como às mudanças nos seus receptores uterinos. Entretanto, pouco concluiu-se até o momento a respeito da ação pontual dos esteróides na patogenia da HEC-Piometra (HADLEY, 1975;DE BOSSCHERE et al, 2002;VERVERIDIS et al, 2004 (SUGIURA et al, 2004).…”

Section: Hormônios Endógenos E Exógenosunclassified

“…Na HEC-mucometra, as cadelas apresentam-se clinicamente saudáveis e as alterações histológicas são representadas por hiperplasia e hipertrofia das glândulas endometriais, além de variação do tamanho dos cistos, presença de edema BOSSCHERE et al, 2002;DE BOSSCHERE et al, 2003). Na HEC-mucometra, a expressão contínua dos receptores de estrógeno (ER) mantém o endométrio responsivo, mesmo em concentrações séricas reduzidas.…”

Section: Classificação Da Hec-piometraunclassified

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Caracterização das alterações hemodinâmicas do útero em cadelas com hiperplasia endometrial cística-piometra

Veiga¹

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Estrogen-α and progesterone receptor expression in cystic endometrial hyperplasia and pyometra in the bitch

Cited by 51 publications

References 23 publications

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Evaluation of cell proliferation and endometrial thickness of bitches in different periods of diestrus

Immunohistochemical evaluation of apoptosis and proliferation in the mucous membrane of selected uterine regions in pre-pubertal bitches exposed to low doses of zearalenone

Caracterização das alterações hemodinâmicas do útero em cadelas com hiperplasia endometrial cística-piometra

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