2020
DOI: 10.1021/acs.biomac.9b01681
|View full text |Cite
|
Sign up to set email alerts
|

Estrone-Decorated Polyion Complex Micelles for Targeted Melittin Delivery to Hormone-Responsive Breast Cancer Cells

Abstract: Tumor targeting has revolutionized cancer research, especially active cellular targeting of nanoparticles, where they are specifically homed to the pathological site to deliver the therapeutics. This strategy, which involves the utilization of affinity ligands on the surface of the nanocarriers, minimizes the nonspecific uptake of nanocarriers and the subsequent harmful side effects in healthy cells. Estrone, one of the mammalian estrogens, has affinity for estrogen receptors (ERα), which are overexpressed in … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
30
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 41 publications
(30 citation statements)
references
References 52 publications
0
30
0
Order By: Relevance
“…Cationic drugs such as peptides or proteins are typically delivered using negatively charged polymers such as poly(acrylic acid). [ 26 ] At low pH values, these polymers are partly protonated assisting with the release of the drug. Depending on the design of the negatively charged polymer, protonation is incomplete and the electrostatic interaction with the cationic drug is only weakened, but not eliminated.…”
Section: Resultsmentioning
confidence: 99%
“…Cationic drugs such as peptides or proteins are typically delivered using negatively charged polymers such as poly(acrylic acid). [ 26 ] At low pH values, these polymers are partly protonated assisting with the release of the drug. Depending on the design of the negatively charged polymer, protonation is incomplete and the electrostatic interaction with the cationic drug is only weakened, but not eliminated.…”
Section: Resultsmentioning
confidence: 99%
“…This drug vehicle system significantly enhanced the cytotoxicity on breast cancer cells compared to native bufalin, with no or few apparent side effects. In a further example, melittin delivered by citric acidfunctionalized Fe 3 O 4 magnetic nanoparticles (Hematyar et al, 2018), carbon nanoparticles (Daniluk et al, 2019) and perfluorocarbon nanoparticles (Soman et al, 2009), or an estrone-appended polyion complex micelle exhibited substantially greater antitumor efficacy against several breast cancer cells (Raveendran et al, 2020). Furthermore, an NCTD-loaded RGD (Arg-Gly-Asp)-decorated lipid-polymer hybrid nanoparticle inhibited TNBC tumor growth and metastasis via attenuating the Wnt/β-catenin pathway more effectively than free NCTD (Li YF et al, 2019).…”
Section: Future Perspectives and Approachesmentioning
confidence: 99%
“… 50 , 51 As a kind of estrogen, estrone (ES) can specifically bind to the ER and has a high affinity to the ER. 52 The presence of ER on the tumor cell membrane could be utilized for the treatment of ovarian cancer cells as a potential target for nanoparticle delivery of drugs. Therefore, using ES as a targeting ligand molecule in the liposomal delivery system could have the ability to deliver more chemotherapy drugs to the ovarian cancer tissues.…”
Section: Introductionmentioning
confidence: 99%