Estudio de la estancia tras laringuectomía total: análisis retrospectivo multivariable de 442 laringuectomías totales

Esteban, Francisco J.; Delgado-Rodrı́guez, Miguel; Mochon, Alain; Solano, Juan José Bedolla; Soldado, L; Solanellas, J

doi:10.1016/s0001-6519(06)78687-3

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…As PCF development seems to be closely linked to inflammation, we focused on readily available clinical inflammation values. Postoperatively elevated temperature has been described as a relevant indicator for PCF in prior studies [3,9,13,19,26]. These results should be interpreted with caution, however, as they are mostly obtained during the early postoperative period when other causes for fever have to be taken into consideration.…”

Section: Clinical Parametersmentioning

confidence: 83%

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Bradykinin Receptor B1 and C-Reactive Protein as Prognostic Factors for Pharyngocutaneous Fistula Development After Laryngectomy

Koob

Pickhard

Buchberger

et al. 2019

Head and Neck Pathol

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Pharyngocutaneous fistulae (PCF) are one of the most common complications after laryngectomy. Predisposing risk factors have been studied, yet knowledge to determine which patients are prone to developing a fistula remains scarce. This study aims to establish prognostic parameters to identify individual patients at risk for PCF development. As PCF and inflammation seem to be interwoven, this work focuses on markers able to detect an inflammatory response. We retrospectively analyzed all patients who had undergone a laryngectomy at our clinic in the years 2007 to 2017 (n = 182). Immunohistochemical expression of bradykinin type 1 and 2 receptor and vascular endothelial growth factor receptor 2 was studied in all available tumor samples. Additionally, the clinical inflammation parameters 'body temperature', 'pain', 'c-reactive protein (CRP)', and 'leucocytes' were postoperatively tracked in all patients. The times between fistula diagnosis, therapeutic approach, and hospital discharge were recorded. We found a strong correlation between inflammation and the formation of a fistula. High bradykinin 1 receptor expression in the tumor samples correlated with postoperative PCF development. Persistently elevated CRP and leukocyte levels beyond the 6th postoperative day were also risk factors. A decreased time lapse between PCF diagnosis and surgical revision clearly correlated with a shorter hospital stay. In this study, we identified a bradykinin 1 receptor positive patient group at high risk for development of PCF. We recommend close monitoring for fistula formation in these patients to ensure timely intervention.

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Section: Clinical Parametersmentioning

confidence: 83%

“…Permanent salivary leakage from the communication leads to ongoing inflammation that inhibits proper wound healing and the onset of complementary therapy. This prolongs hospitalization, increases the costs of treatment, and, most importantly, strains the patient's physical and psychological well-being [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Bradykinin Receptor B1 and C-Reactive Protein as Prognostic Factors for Pharyngocutaneous Fistula Development After Laryngectomy

Koob

Pickhard

Buchberger

et al. 2019

Head and Neck Pathol

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Pharyngocutaneous fistulas after total laryngectomy or pharyngolaryngectomy: Place of video‐fluoroscopic swallowing study

Carsuzaa¹,

Capitaine

Ferrié³

et al. 2020

Head & Neck

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Background: Specify place of video-fluoroscopic swallowing study (VFS) in the decision of oral refeeding after total pharyngolaryngectomy. Methods: At postoperative day 7, a blue dye testing was performed. If negative, a VFS was performed looking for a blind fistula. If this exam was negative, oral refeeding was started, but if a blind fistula was observed, cervical compression bandage was performed. Results: In 186 patients, a VFS was performed for 142 patients with negative blue dye testing. It was negative for 98 patients (69%) and positive for 44 patients (31%) (blind fistula). Patients had a probability of 7.1% to have a secondary pharyngocutaneous fistula (PCF) if the VFS was negative, and 15.9% if it was positive. No risk factor for the development of a secondary PCF or a blind fistula emerged from our analysis. Conclusion: VFS should be performed before any oral refeeding in all patients operated with a total pharyngolaryngectomy.

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Derivation of a clinical decision rule for predictive factors for the development of pharyngocutaneous fistula postlaryngectomy

Cecatto

Monteiro‐Soares

Henriques

et al. 2015

Brazilian Journal of Otorhinolaryngology

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Estudio de la estancia tras laringuectomía total: análisis retrospectivo multivariable de 442 laringuectomías totales

Cited by 7 publications

References 17 publications

Bradykinin Receptor B1 and C-Reactive Protein as Prognostic Factors for Pharyngocutaneous Fistula Development After Laryngectomy

Bradykinin Receptor B1 and C-Reactive Protein as Prognostic Factors for Pharyngocutaneous Fistula Development After Laryngectomy

Pharyngocutaneous fistulas after total laryngectomy or pharyngolaryngectomy: Place of video‐fluoroscopic swallowing study

Derivation of a clinical decision rule for predictive factors for the development of pharyngocutaneous fistula postlaryngectomy

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