Estudo do efeito da amiodarona sobre o peso corpóreo e sobre determinantes morfológicos e citopatológicos do pulmão em ratos machos e fêmeas das linhagens Wistar, Wistar-Kyoto e SHR

Queluz, Thais Thomaz; Silva, Maria Helena De Castro E; Zanatti, Silméia Garcia; Oliveira, Frederico Sobral De; Bazan, Rodrigo; Defaveri, Júlio

doi:10.1590/s0102-35862002000600003

Cited by 3 publications

(2 citation statements)

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“…This is because the data obtained was an average, however, the animals get sick and die differently. Thus, after the mortality of the weaker mice, there is an increase in the average weight, with a rise in the curve which does not represent clinical improvement, but the individuality of response to the infection, which was observed after the completion of several experiments (Queluz et al, 2002). In rebuttal, the individual data would provide a better visualization of the weight evolution, nevertheless, there is limited feasibility, due to the large number of samples used in experiments with mice (Ferreira et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Parameters for evaluation of clinical trial in mice infected with Trypanosoma cruzi

Falkowski¹,

Sandri

Tiyo³

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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The effectiveness of clinical parameters in the evaluation of Trypanosoma cruzi infection was analyzed in male Swiss mice at 8 weeks old Animals were divided into HG (healthy) and IG (1400 trypomastigotes, intraperitoneally, Y strain -Trypanosoma cruzi). Quantitative and qualitative parameters were evaluated in non-consecutive days in the period, from 7 th -11 th and 15 th -18 th days of infection. There were significant differences (P<0.05) between both groups in both periods regarding water consumption, abdominal circumference and weight. The second group presented differences in amount of excreta, body temperature, move-up and mortality. There was no difference (P>0.05) between the groups in food consumption, exploration of self-cleaning and skin staining. The fecal feature differed between the groups in the second period. The occurrence of isolation was not practical. Differences were observed in the hair between groups, although the parameter had been interfered by fights between animals. The consumption of water, feed, excreta production, characteristic of the faeces, body temperature, abdominal circumference, move up, weight and mortality parameters are easy to be measured and effective in clinical differentiation of healthy mice infected with T. cruzi, elected in protocols for clinical study with mice, which is the first work to gather information of qualitative and quantitative clinical parameters evaluated in these animals. Keywords: clinical analysis, Chagas disease, experimental infection, mice, Trypanosoma cruzi RESUMO Analisou-se a eficiência de parâmetros clínicos na avaliação da infecção pelo Trypanosoma cruzi em camundongos suíços, machos de 8 semanas. Os grupos foram divididos em GS (sadios) e GI (1400 tripomastigotas, intraperitoneal, cepa Y -Trypanosoma cruzi

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