2007
DOI: 10.1038/sj.jp.7211779
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ETCare: a randomized, controlled, masked trial comparing two solutions for upper airway care in the NICU

Abstract: Objective: Small quantities of normal saline are sometimes instilled into the endotracheal tube of intubated neonates, to assist with the removal of thick secretions and maintain patency of the endotracheal tube. However, saline is detrimental to the innate immune system of the upper airway mucosa, rapidly unfolding and inactivating antimicrobial peptides such as LL-37. We previously reported the preparation and feasibility testing of 'ETCare', a low-sodium, physiologically based solution for airway care, and … Show more

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