Ethanol affects acylated and total ghrelin levels in peripheral blood of alcohol-dependent rats

Szulc, Michał; Mikołajczak, Przemysław Ł.; Geppert, Bogna; Wachowiak, Roman; Dyr, Wanda; Bobkiewicz-Kozlowska, T.

doi:10.1111/adb.12025

Cited by 33 publications

(19 citation statements)

References 52 publications

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“…Therefore, searching for a new substances that might affect development of tolerance seems to be justified. The aim of our study was to examine the influence of Sal, the active compound of R. rosea, on the development of alcohol tolerance in rats according to model proposed by Crabbe [25], subsequently successfully applied in our team [26]. Development of tolerance to ethanol can be evaluated on changes in the hypothermic and sedative action of ethanol.…”

Section: Discussionmentioning

confidence: 99%

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Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

et al. 2018

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SummaryIntroduction: In recent years, the search for potential neuroprotective properties of salidroside and its ability to influence the activity of nervous system become the subject of intense studies of many research groups. None of these studies, however, include an attempt to determine the effect of salidroside on the course of alcohol tolerancein vivo.Objective: The aim of this study was to investigate the ability of salidroside to inhibit the development of alcohol tolerance in rats, determining whether the effect of its action may occur in a dose-dependent manner, reducing both metabolic and central tolerance without affecting body temperature in control rats.Methods: Male Wistar rats were injected daily with ethanol at a dose of 3 g/kg for 9 consecutive days to produce ethanol tolerance. Salidroside in two doses (4.5 mg/kg and 45 mg/kgb.w.) orvehiculumwas administered orally. On the 1st, 3rd, 5th and 8th day a hypothermic effect of ethanol was measured, while the loss of righting reflex procedure was performed on the 2nd, 4th, 6th and 7th day. On the 9th day rats were treated with salidroside, sacrificed 1 h after ethanol injections and blood was collected for blood-ethanol concentration measurement.Results: Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to hypothermic and sedative effects of ethanol, whereas insignificant elevation of blood-ethanol concentration was observed. The dose of 4.5 mg/kgb.w.had minimal effect, only small inhibition of tolerance to hypothermic action was observed. Salidroside affected neither body mass growth nor body temperature in non-alcoholic (control) rats.Conclusions: Results of the study indicate that salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic effect of ethanol. Observed inhibition of tolerance to the sedative effect of ethanol seems to be associated with salidroside influence on the central nervous system. A comprehensive explanation of the abovementioned observations requires further pharmacological and pharmacodynamic studies.

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Section: Discussionmentioning

confidence: 99%

“…Sampling was performed with Perkin Elmer AutoSystem XL GC with Headspace Sampler Turbomatrix 40, equipped with two capillary columns Elite BAC-1, BAC-2 (Perkin Elmer, length: 30 m, diameter: 0.32 mm, film thickness: 1.8 μm, software: Totalchrom Workstation ver. 6.2.0) [26].…”

Section: Measurement Of Ethanol Concentration In Bloodmentioning

confidence: 99%

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

et al. 2018

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“…However, another study showed that 10 months of alcohol consumption decreased GHS-R1a expression in the VTA of rats (Suchankova et al, 2013). P rats and WHP rats showed greater reductions in plasma acyl-ghrelin levels after alcohol consumption relative to NP and WLP rats (Szulc et al, 2013). Together these studies imply that alcohol affects circulating ghrelin and central ghrelin signaling.…”

Section: Ghrelinmentioning

confidence: 99%

Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders

et al. 2014

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Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-limbic circuitry and, in turn, regulate addictive behaviors. Given that alcohol is a source of energy and an addictive substance, it is not surprising that increasing evidence supports a role for gut-brain peptides specifically in alcohol use disorders (AUD). In this review, we discuss the effects of several gut-brain peptides on alcohol-related behaviors and the potential mechanisms by which these gut-brain peptides may interfere with alcohol-induced changes in corticostriatal-limbic circuitry. This review provides a summary of current knowledge on gut-brain peptides focusing on five peptides: neurotensin, glucagon-like peptide 1, ghrelin, substance P, and neuropeptide Y. Our review will be helpful to develop novel therapeutic targets for AUD.

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“…; Szulc et al . ). Furthermore, central and intra‐VTA administration of ghrelin increased alcohol intake in mice (Jerlhag et al .…”

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The role of ghrelin in drug and natural reward

Vengeliene

2013

Addiction Biology

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Ghrelin is a protein that has been given special attention in both nutrition and addiction research during the last decade. Consequently, a vast amount of information has been accumulated concerning the role of ghrelin in natural and drug reward. We are now in the position to ask whether the ghrelin system could be targeted to treat maladaptive behaviours such as obesity and drug addiction. Indeed, ghrelin research has demonstrated that blocking the activity of ghrelin receptors may be effective in reducing the consumption of both food and drugs of abuse. This review will give a short overview of our current knowledge about the ghrelin system in the context of drug and natural rewards as well as the possibility of developing potential ghrelin-based treatments.

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Ethanol affects acylated and total ghrelin levels in peripheral blood of alcohol-dependent rats

Cited by 33 publications

References 52 publications

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders

The role of ghrelin in drug and natural reward

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