Ethanol Extracts from the Aerial Parts of Inula japonica and Potentilla chinensis Alleviate Airway Inflammation in Mice That Inhaled Particulate Matter 10 and Diesel Particulate Matter

Jung, Seang-Hwan; Chung, Kyung-Sook; Na, Chang-Seon; Ahn, Hye-Shin; Shin, Yu-Kyong; Lee, Kyung-Tae

doi:10.3390/nu15214599

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Apigenin glucoside malonate Dittrichia viscosa [71] Apigenin 7-O-glucuronide (CID: 5319484) Synonym: Scutellarin A Inula japonica [72] Apigenin O-hexuronide Telekia speciosa [63] Apigenin dihexoside Pulicaria vulgaris [73] Apigenin Asteriscus graveolens [192] [123]…”

Section: Synonym: Salipurpinmentioning

confidence: 99%

“…Except for the most found caffeoylquinic acids, monoacyl-, diacyl-and triacylquinic acids (conjugates with ferulic, p-coumaric and caffeic acid) or caffeoylquinates substituted with short-chain organic acids (isobutyric, methylbutyric and others) were often identified in the extracts of the Inuleae-Inulinae, mostly using HPLC-MS techniques [54,63,76,99,124,125,131,143,161,168,172,184,215,224,[328][329][330][331][332]. Metabolomic studies, performed using the hyphenated methods, revealed the presence of conjugates of hydroxycinnamic acids with shikimic acid in D. cappa [329], D. nervosa [330] and D. viscosa [170] and conjugates of hydroxycinnamic acids with aldaric acids in B. megacephala, B. riparia [124], B. speciosissimum [161], C. divaricatum [328], C. glutinosus [76], D. viscosa [136,333], I. helenium [334], I. japonica [72], I. sarana [54], P. spinosa [205], P. vulgaris [73] and P. inuloides [184]. Caffeoyltartaric acid (caftaric acid) and 2,3dicaffeoyltartaric acid (chicoric acid) were isolated from roots of I. helenium [335].…”

Section: Hydroxycinnamatesmentioning

confidence: 99%

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Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Malarz,

Michalska,

Stojakowska

2024

Preprint

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Polyphenols are ubiquitous plant metabolites that demonstrate biological activities essential to the plant-environment interactions. They are of interest to plant food consumers, as well as to the food, pharmaceutical and cosmetic industry. The class of the plant metabolites comprises both widespread (chlorogenic acids, luteolin, quercetin) and unique compounds of diverse chemical structures but of the common biosynthetic origin. Polyphenols, next to sesquiterpenoids are regarded as the major class of the Inuleae-Inulinae metabolites responsible for the pharmacological activity of medicinal plants from the subtribe (Blumea spp., Dittrichia spp., Inula spp., Pulicaria spp. and others). Recent decades have brought a rapid development of molecular and analytical techniques which resulted in better understanding of the taxonomic relationships within the Inuleae tribe and in a plethora of data concerning the chemical constituents of the Inuleae-Inulinae. The current taxonomical classification has introduced changes in the well-established botanical names and rearranged the genera based on molecular plant genetic studies. The newly created chemical data together with the earlier phytochemical studies may provide some complementary information on biochemical relationships within the subtribe. Moreover, they may at least partly explain pharmacological activities of the plant preparations traditionally used in therapy. The current review aimed to systematize the knowledge on the polyphenols of the Inulae-Inulinae.

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Section: Synonym: Salipurpinmentioning

confidence: 99%

Section: Hydroxycinnamatesmentioning

confidence: 99%

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Malarz,

Michalska,

Stojakowska

2024

Preprint

View full text Add to dashboard Cite

show abstract

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Malarz,

Michalska,

Stojakowska

2024

Molecules

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Polyphenols are ubiquitous plant metabolites that demonstrate biological activities essential to plant–environment interactions. They are of interest to plant food consumers, as well as to the food, pharmaceutical and cosmetic industry. The class of the plant metabolites comprises both widespread (chlorogenic acids, luteolin, quercetin) and unique compounds of diverse chemical structures but of the common biosynthetic origin. Polyphenols next to sesquiterpenoids are regarded as the major class of the Inuleae-Inulinae metabolites responsible for the pharmacological activity of medicinal plants from the subtribe (Blumea spp., Dittrichia spp., Inula spp., Pulicaria spp. and others). Recent decades have brought a rapid development of molecular and analytical techniques which resulted in better understanding of the taxonomic relationships within the Inuleae tribe and in a plethora of data concerning the chemical constituents of the Inuleae-Inulinae. The current taxonomical classification has introduced changes in the well-established botanical names and rearranged the genera based on molecular plant genetic studies. The newly created chemical data together with the earlier phytochemical studies may provide some complementary information on biochemical relationships within the subtribe. Moreover, they may at least partly explain pharmacological activities of the plant preparations traditionally used in therapy. The current review aimed to systematize the knowledge on the polyphenols of the Inulae-Inulinae.

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Lysimachia mauritiana Lam. Extract Alleviates Airway Inflammation Induced by Particulate Matter Plus Diesel Exhaust Particles in Mice

Sung,

Kim,

Yang

et al. 2024

Nutrients

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Exposure to air pollution poses a risk to human respiratory health, and a preventive and therapeutic remedy against fine dust-induced respiratory disease is needed. Background/Objectives: The respiratory-protective effects of Lysimachia mauritiana (LM) against airway inflammation were evaluated in a mouse model exposed to a fine dust mixture of diesel exhaust particles and particulate matter with a diameter of less than 10 µm (PM10D). Methods: To induce airway inflammation, PM10D was intranasally injected into BALB/c mice three times a day for 12 days, and LM extracts were given orally once per day. The immune cell subtypes, histopathology, and expression of inflammatory mediators were analyzed from the bronchoalveolar lavage fluid (BALF) and lungs. Results: LM alleviated the accumulation of neutrophils and the number of inflammatory cells in the lungs and the BALF of the PM10D-exposed mice. LM also reduced the release of inflammatory mediators (MIP-2, IL-17, IL-1α, CXCL1, TNF-α, MUC5AC, and TRP receptor channels) in the BALF and lungs. Lung histopathology was used to examine airway inflammation and the accumulation of collagen fibers and inflammatory cells after PM10D exposure and showed that LM administration improved this inflammation. Furthermore, LM extract inhibited the MAPK and NF-κB signaling pathway in the lungs and improved expectoration activity through an increase in phenol red release from the trachea. Conclusions: LM alleviated PM10D-exposed neutrophilic airway inflammation by suppressing MAPK/NF-κB activation. This study indicates that LM extract may be an effective therapeutic agent against inflammatory respiratory diseases.

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Ethanol Extracts from the Aerial Parts of Inula japonica and Potentilla chinensis Alleviate Airway Inflammation in Mice That Inhaled Particulate Matter 10 and Diesel Particulate Matter

Cited by 3 publications

References 30 publications

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Lysimachia mauritiana Lam. Extract Alleviates Airway Inflammation Induced by Particulate Matter Plus Diesel Exhaust Particles in Mice

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