Ethanol induces interdigitated gel phase (LβI) between lamellar gel phase (Lβ′) and ripple phase (Pβ′) in phosphatidylcholine membranes: a scanning density meter study

Ohki, Kazuo; Tamura, Kazuo; Hatta, Ichiro

doi:10.1016/0005-2736(90)90169-o

Cited by 82 publications

(44 citation statements)

References 39 publications

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“…Maruyama et al found coexisting phases of L α with L β I and L β′ with L β I in DPPC vesicles in the presence of the anesthetic tetracaine [16]. Also, the L β I to P β′ to L α pathway has been observed by Ohki et al with increasing temperature [17]. It should be noted however that this reasoning has been applied primarily to shoulder peaks seen right after the threshold concentration and not within the high concentration range we are studying.…”

Section: Discussionmentioning

confidence: 73%

Effects of butanol isomers on dipalmitoylphosphatidylcholine bilayer membranes

Reeves

Schawel

Wang

et al. 2007

Biophysical Chemistry

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Section: Discussionmentioning

confidence: 73%

Effects of butanol isomers on dipalmitoylphosphatidylcholine bilayer membranes

Reeves

Schawel

Wang

et al. 2007

Biophysical Chemistry

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“…It is known that the presence of alcohol molecules in a lipid bilayer can change the bilayer phase diagram [164][165][166][167], as illustrated in Fig. 21(a), which shows the typical phases of a lipid/alcohol bilayer as a function of temperature and alcohol concentration.…”

Section: Alcoholsmentioning

confidence: 99%

“…These voids are energetically unfavorable and thus the system minimizes its the energy by the formation of an interdigitated phase. Due to interdigitation, the system gains energy because of the stronger van der Waals interaction [135,165,169] in the interdigitated phase compared to the noninterdigitated case, and increases the entropy by replacing the highly ordered water molecules at the interface by alcohol molecules [135,159,170]. Since the tail ends of the alcohol molecules shield the tail ends of the lipids from the interfacial water, the energy cost in the formation of the interdigitated phase is further lowered.…”

Section: Alcoholsmentioning

confidence: 99%

Mesoscopic models of biological membranes

Venturoli¹,

et al. 2006

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Phospholipids are the main components of biological membranes and dissolved in water these molecules self-assemble into closed structures, of which bilayers are the most relevant from a biological point of view. Lipid bilayers are often used, both in experimental and by theoretical investigations, as model systems to understand the fundamental properties of biomembranes. The properties of lipid bilayers can be studied at different time and length scales. For some properties it is sufficient to envision a membrane as an elastic sheet, while for others it is important to take into account the details of the individual atoms. In this review, we focus on an intermediate level, where groups of atoms are lumped into pseudo-particles to arrive at a coarse-grained, or mesoscopic, description of a bilayer, which is subsequently studied using molecular simulation.The aim of this review is to compare various strategies to coarse grain a biological membrane. The conclusion of this comparison is that there can be many valid different strategies, but that the results obtained by the various mesoscopic models are surprisingly consistent. A second objective of this review is to illustrate how mesoscopic models can be used to obtain a better understanding of experimental systems. The advantage of coarse-grained models is that these can be simulated very efficiently, so that phenomena involving large systems, or requiring a large number of simulations, can be studied in detail. This is illustrated with the study of the relation between the phase behavior of a membrane and the structure of the phospholipids, and the membrane structural changes due to molecules (such as alcohols, cholesterol and anesthetics) adsorbed to the membrane. We then discuss the effect of transmembrane peptides on the local structure of a membrane and the mechanism of vesicle fusion and fission.

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“…It is well known that the DPPC bilayer membrane exhibits four bilayer phases in turn, namely the lamellar crystal, lamellar gel, ripple gel and liquid crystalline phases, as temperature increases. Recent studies on the phase behavior of DPPC bilayer membrane have suggested that there exists an interdigitated gel phase, in which the hydrocarbon chains from apposing monolayers become interdigitated with the chains, induced by high concentration of alcohols 26,[36][37][38] and some local anesthetics such as tetracaine and dibucaine 32,33) as well as high pressure 24,39) . Tetracaine and dibucaine behave as a cationic surfactant because of their hydrophobic nature and have the critical micelle concentration of 128 and 79 mmol kg -1 , respectively 3,4) .…”

mentioning

confidence: 99%