Ethanol metabolizing system in drosophila. Aldehyde dehydrogenase: Functional aspects in adult and during development

Barcin, Francoise; Côté, Johanne; Hin, Gary Lau You; Chawla, S. S.; Radouco-Thomas, Simone

doi:10.1016/0278-5846(86)90071-0

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…While it has been clear for some time that Drosophila contain an active ALDH (Lie´taert et al, 1985;Garcin et al, 1986 ;Leal & Barbancho, 1992), ALDH was initially hypothesized to be less important for ethanol metabolism in Drosophila than in mammals (Geer et al, 1985 ;Heinstra et al, 1989). This claim followed the discovery that Drosophila ADH is capable of oxidizing acetaldehyde to acetate by itself (Heinstra et al, 1983;Eisses et al, 1985;Geer et al, 1985; but see Henehan et al, 1995, for evidence that this ability may be more limited than concluded by the earlier studies).…”

Section: Introductionmentioning

confidence: 99%

Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster

Fry

Saweikis

2006

Genet. Res.

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The enzyme aldehyde dehydrogenase (ALDH) is essential for ethanol metabolism in mammals, converting the highly toxic intermediate acetaldehyde to acetate. The role of ALDH in Drosophila has been debated, with some authors arguing that, at least in larvae, acetaldehyde detoxification is carried out mainly by alcohol dehydrogenase (ADH), the enzyme responsible for converting ethanol to acetaldehyde. Here, we report the creation and characterization of four null mutants of Aldh, the putative structural locus for ALDH. Aldh null larvae and adults are poisoned by ethanol concentrations easily tolerated by wild-types; their ethanol sensitivity is in fact comparable to that of Adh nulls. The results refute the view that ALDH plays only a minor role in ethanol detoxification in larvae, and suggest that Aldh and Adh may be equally important players in the evolution of ethanol resistance in fruit-breeding Drosophila.

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Section: Introductionmentioning

confidence: 99%

Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster

Fry

Saweikis

2006

Genet. Res.

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“…However, ethanol-rich substrates provide some protection against parasites for D. melanogaster, while D. simulans appears to mount a stronger immune response instead (i.e., fight or flight) (Lefèvre et al, 2012;Milan, Kacsoh, & Schlenke, 2012). The relationship between ethanol, parasite resistance, adult and larval tolerance, and caloric benefit is not entirely clear despite a number of studies on the subject (Chakir et al, 1993;Dorado & Barbancho, 1984;Fry et al, 2004Fry et al, , 2008Garcin, Cote, Lau You Hin, Chawla, & Radouco-Thomas, 1986;Hodges, Laskowski, Squadrito, De Luca, & Leips, 2013;Kerver & Rotman, 1987;McKechnie & Morgan, 1982;McKenzie & McKechnie, 1979;Mercot et al, 1994;Milan et al, 2012;Muhammed-Ali & Burnet, 1995;Thomson et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Conservation of social effects (Ψ) between two species of Drosophila despite reversal of sexual dimorphism

Signor

Abbasi

Marjoram

et al. 2017

Ecology and Evolution

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Indirect genetic effects (IGEs) describe the effect of the genes of social partners on the phenotype of a focal individual. Here, we measure indirect genetic effects using the “coefficient of interaction” (Ψ) to test whether Ψ evolved between Drosophila melanogaster and D. simulans. We compare Ψ for locomotion between ethanol and nonethanol environments in both species, but only D. melanogaster utilizes ethanol ecologically. We find that while sexual dimorphism for locomotion has been reversed in D. simulans, there has been no evolution of social effects between these two species. What did evolve was the interaction between genotype‐specific Ψ and the environment, as D. melanogaster varies unpredictably between environments and D. simulans does not. In this system, this suggests evolutionary lability of sexual dimorphism but a conservation of social effects, which brings forth interesting questions about the role of the social environment in sexual selection.

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Effects of dietary ethanol, acetaldehyde, 2-propanol and acetone on the variation of several enzyme activities involved in alcohol metabolism of Drosophila melanogaster adults

Barbancho

1992

Insect Biochemistry and Molecular Biology

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Ethanol metabolizing system in drosophila. Aldehyde dehydrogenase: Functional aspects in adult and during development

Cited by 6 publications

References 25 publications

Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster

Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster

Conservation of social effects (Ψ) between two species of Drosophila despite reversal of sexual dimorphism

Effects of dietary ethanol, acetaldehyde, 2-propanol and acetone on the variation of several enzyme activities involved in alcohol metabolism of Drosophila melanogaster adults

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