Ethanol solution-modified supercritical carbon dioxide extraction of triterpenic acids from Hedyotis corymbosa with ultrasound assistance and determination of their solubilities

Yang, Yu; Wei, Ming-Chi

doi:10.1016/j.seppur.2015.06.037

Cited by 25 publications

(10 citation statements)

References 48 publications

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“…At all five extraction temperatures, the theoretical solubility increased substantially with pressure because of the increase in the supercritical CO 2 density. This result is similar to those of most studies using SC CO 2 dynamic extraction [33,34].…”

Section: Theoretical Solubility Of Volatile Oils and Modelssupporting

confidence: 91%

Insights into the Supercritical CO2 Extraction of Perilla Oil and Its Theoretical Solubility

et al. 2021

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In the current research, the supercritical carbon dioxide (SCCO2) procedure was used to extract volatile oils from perilla leaves. The yields of the volatile oils and the four main constituents, limonene, perillaldehyde, β-caryophyllene, and (Z,E)-α-farnesene obtained by the SCCO2 procedure were 1.31-, 1.12-, 1.04-, 1.05-, and 1.07-fold higher than those obtained by the hydrodistillation technique, respectively. Furthermore, the duration and temperature of extraction were 40 min and 45 °C lower, respectively, in the former procedure compared to the latter technique. These advantages reveal that SCCO2 not only obtains high-quality extracts, but also meets the requirements of green environmental protection. The theoretical solubilities of the volatile oils acquired by the SCCO2 dynamic extraction at various temperatures and pressures were 1.385 × 10−3–8.971 × 10−3 (g oil/g CO2). Moreover, the three density-based models were well correlated with these theoretical solubility data, with a high coefficient of determination and low average absolute relative deviation.

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Section: Theoretical Solubility Of Volatile Oils and Modelssupporting

confidence: 91%

Insights into the Supercritical CO2 Extraction of Perilla Oil and Its Theoretical Solubility

et al. 2021

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“…Recently, some research reports on Hedyotis corymbosa (HC) and its compositions expression antifungal, antioxidant, anti-injury, analgesic, and liver protection [ 5 , 7 , 8 ]. According to the preparation process and primary active ingredients of previously studies, the proteins, carbohydrates, phenols, iridoids, tannins, flavonoids, saponins, steroids, terpenoids, and glycosides were the main focus and accounted for the major constituents [ 9 , 10 ]. However, research into some other components like polysaccharides is quite limited.…”

Section: Introductionmentioning

confidence: 99%

Extraction, Characterization, Antioxidant, and Immunostimulatory Activities of Polysaccharides from Hedyotis corymbosa

Lin

Xiong

Zhao

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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In this study, optimization of enzyme-assisted extraction, purification, characterization, and its bioactivities of polysaccharides from Hedyotis corymbosa (HCP) was investigated. It was found that the optimum extraction conditions were 3% of enzyme concentration (X1), 30 of liquid-to-solid ratio (X2), 56°C of extraction temperature (X3), 200W of ultrasonic power (X4), 10 min of extraction time (X5), and 5 of pH value (X6). Under optimum conditions, the experimental yield (4.10 ± 0.16%) was closed to the predicted value (4.02%). The crude HCP was further purified using DEAE-52 and Sephadex G-150 gel column, and a major polysaccharide fraction from HCP, designed as HCP-1a with molecular weight of 33.9 kDa, was obtained. The HCP and HCP-1a were characterized by chemical analysis, FT-IR, and HPLC. For antioxidant activities in vitro, HCP possessed strong hydroxyl radical scavenging, DPPH radical scavenging, and Fe2+ chelating activities. In subsequent immunostimulatory studies, significantly decreased NO, IL-1β, and TNF-α concentrations were observed in both of HCP and HCP-1a treated RAW264.7 cells. Therefore, this study may indicate some insights into the application of polysaccharides from Hedyotis corymbosa as potential natural antioxidants and immunostimulants.

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“…Apart from chromatographic methods, extraction methods should be performed and optimized along with the corresponding analytical techniques, extraction temperature, time, and cycles, solvents used, solvent‐to‐material ratio, presoaking time of the sources, and properties of the compound itself. Some of the methods that can be used to extract triterpenes, include Soxhlet extraction, heat reflux extraction, maceration extraction, stirring extraction, UAE, MAE, SFE, and pressurized fluid extraction (PFE) . Among these methods, Soxhlet extraction, heat reflux extraction, maceration extraction, and stirring extraction are relatively simple and have a low cost.…”

Section: Discussionmentioning

confidence: 99%

“…Some of the methods that can be used to extract triterpenes, include Soxhlet extraction, heat reflux extraction, maceration extraction, stirring extraction, UAE, MAE, SFE, and pressurized fluid extraction (PFE) [25, [65][66][67][68][69][70][71][72][73]. Among these methods, Soxhlet extraction, heat reflux extraction, maceration extraction, and stirring extraction are relatively simple and have a low cost.…”

Section: F I G U R E 1 Methods For the Analysis Of Triterpenesmentioning

confidence: 99%

Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

Bing

et al. 2017

J of Separation Science

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Triterpenes are a major class of chemical compounds found in natural plants and can be categorized into acyclic triterpenoids, monocyclic triterpenoids, tricyclic triterpenoids, tetracyclic triterpenoids, and pentacyclic triterpenoids. Among them, pentacyclic triterpenoids have gained more extensive attention due to their biological activities, including anti-inflammation, antibacterial, antioxidation, antitumor, anti-HIV, hepatoprotection, and immunological adjuvant properties. In this review, we summarize the extraction and analytical methods for pentacyclic triterpenoids, where more than 56 triterpenes from 49 kinds of plants were involved. The analysis methods include gas chromatography, liquid chromatography, capillary electrophoresis, thinlayer chromatography, supercritical fluid chromatography, NMR spectroscopy, and X-ray spectroscopy. This review provides valuable reference for the determination of pentacyclic triterpenoids in medicinal plants.

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Ethanol solution-modified supercritical carbon dioxide extraction of triterpenic acids from Hedyotis corymbosa with ultrasound assistance and determination of their solubilities

Cited by 25 publications

References 48 publications

Insights into the Supercritical CO2 Extraction of Perilla Oil and Its Theoretical Solubility

Insights into the Supercritical CO2 Extraction of Perilla Oil and Its Theoretical Solubility

Extraction, Characterization, Antioxidant, and Immunostimulatory Activities of Polysaccharides from Hedyotis corymbosa

Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

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