2012
DOI: 10.1248/bpb.b12-00547
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Ethanol Sulfation by the Human Cytosolic Sulfotransferases: A Systematic Analysis

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Cited by 18 publications
(9 citation statements)
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“…Altogether, these results would suggest that UGTs have higher metabolic activity towards ethanol than SULTs both in vivo and in the in vitro models of hepatocytes used in this study. SULT1A1 and SULT2A1 are the main SULT isoforms expressed in liver (Riches et al, 2009;Kurogi et al, 2012;Stachel and Skopp 2016). Here, we confirmed that SULT1A1 and SULT2A1 mRNA are expressed at comparable levels between HepaRG and HH.…”
Section: Discussionsupporting
confidence: 80%
“…Altogether, these results would suggest that UGTs have higher metabolic activity towards ethanol than SULTs both in vivo and in the in vitro models of hepatocytes used in this study. SULT1A1 and SULT2A1 are the main SULT isoforms expressed in liver (Riches et al, 2009;Kurogi et al, 2012;Stachel and Skopp 2016). Here, we confirmed that SULT1A1 and SULT2A1 mRNA are expressed at comparable levels between HepaRG and HH.…”
Section: Discussionsupporting
confidence: 80%
“…For example, the expression of SULT1A3 was found to be induced by its prototype substrate, dopamine, via ERK pathway in SK-N-MC and SH-SY5Y human neuroblastoma cells. 65) Ethanol has been shown to induce ethanol-sulfating SULTs, 66,67) SULT1A1 and SULT1E1, in cultured HepG2 human hepatoma cells. 68) Interestingly, 17β-estradiol, a substrate for SULT1A1 and SULT1E1, was demonstrated to be capable of inducing SULT2A1, implying that the sulfation of androgens, which are estrogen precursors, is regulated by 17β-estradiol.…”
Section: Regulation Of Sult Expression and Activitymentioning
confidence: 99%
“…EtS is another minor, direct alcohol metabolite, produced through conjugation with sulfate. This reaction is carried out by cytosolic sulfotransferase enzymes [ 84 ]. EtG is primarily used to detect heavy alcohol use.…”
Section: Breath Testmentioning
confidence: 99%