Ethical Principles for Handling Laboratory Animals in an Experiment with Pathogenic Biological Agents of the I-II Groups

Abstract

Current international and major part of national documents, regulating experiments on laboratory animals, is set out in Bioethics Convention 3"R". Presently this 3"R" principle is still relevant and commonly accepted global standard. Objective of the study was to verify the compliance of the staff at the institute with the ethical principles of biological safety when handling laboratory animals infected with pathogenic biological agents (PBA) of the I-II groups, performing diagnostic, experimental, and manufacturing activities. Results and discussion. Carried out analysis of ethical principle implementation, when working with biomodels infected with pathogenic biological agents of the I-II groups, performing scientific and manufacturing activities shows that operational procedures comply with the requirements of biological safety and regulations of ethical code, as well as international standards for humane treatment to animals in biomedical investigations. Conclusions. The work with laboratory animals infected with PBA of the I-II groups at the premises of RusRAPI "Microbe" meets the requirements of biological safety and norms of ethical code. Experiments on animals are aimed at obtainment of new scientific knowledge, preservation and improvement of human health, and also monitoring of natural foci of particularly dangerous infections following the rules of 3"R" bioethical concept.

Efficiency of Using the Hydrogen Peroxide Vapor Generator “Fhileas 75” for Disinfection of the Air Ducts of separately Ventilated system for Infected Animal Housing

“…ивс представляет собой установку подготовки воздуха (с созданием разряжения или избыточного давления воздуха, который на входе и выходе очищается предфильтрами и нерафильтрами н13 или н14) и стеллаж с клетками для содержания экспериментальных животных различных размеров, в зависимости от их вида. изолированное содержание инфицированных биомоделей в ивс исключает перекрестное заражение лабораторных животных различными инфекциями и минимизирует риски заражения персонала вивария [5,6].…”

Effectiveness of the “Sterius 60” SHF Radiation Installation for Disinfection of Objects Contaminated with PBA of Groups I–IV, when Working with Infected Biomodels

“…обеспечение биологической безопасности в лаборатории при выполнении диагностической, производственной и экспериментальной работы достигается строгим выполнением системы организационных, медико-биологических и инженерно-технических мероприятий и средств, направленных на защиту работающего персонала, населения и среды обитания человека от воздействия пба [1][2][3][4].…”