Ethnic differences in heterotopic ossification following total hip arthroplasty

Davis, Gershan; Patel, Ripal; Tan, Timothy L.; Alijanipour, Pouya; Naik, Tejal U.; Parvızı, Javad

doi:10.1302/0301-620x.98b6.36050

Cited by 20 publications

(22 citation statements)

References 48 publications

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“…Clinical risk factors for HO after THA include male sex, hypertrophic osteoarthritis, ankylosing spondylitis, hip ankylosis, and African-American ethnicity that suggest a common, complex aetiology. 7,8 Currently, there are no effective, mechanism-based treatments for HO, and thus identification of focussed, actionable drug targets is required.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification

Hatzikotoulas

Pickering

Clark

et al. 2019

Preprint

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Heterotopic ossification (HO) is bone formation that occurs after trauma within tissues that do not normally have the property of ossification, resulting in pain and disability.The genetic architecture of HO remains unclear. In the first genome-wide association studies of this disease, we identify the human-only long non-coding RNA-encoding gene CASC20 as a robust, replicating susceptibility locus for HO and KIF26B as a potential severity locus. We find that both CASC20 and KIF26B are expressed in human bone. Both CASC20 and KIF26B expression is upregulated upon BMP2 induced osteogenic differentiation in primary human mesenchymal stem cells, followed by RUNX2 and OSTERIX upregulation and mineralised nodule formation. A CRISPR-Cas9 mediated knockout of Kif26b inhibits BMP2-induced Runx2, Sp7/Osterix, Col1A1, Alp, and Bglap/Osteocalcin expression in a murine myocyte model of osteogenic trans-differentiation, and prevents mineralised nodule formation. These studies provide the first insights into the heritable biology of common, complex HO.

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Section: Introductionmentioning

confidence: 99%

Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification

Hatzikotoulas

Pickering

Clark

et al. 2019

Preprint

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“…Due to the wound problems associated with radiation, non-steroidal anti-inflammatory medications are preferred by the senior surgeon but this could present some bias to the results although 2 patients were in the workers compensation cohort that received radiation and one was y were in the non-workers compensation group [20]. Lastly, gender and ethnicity have been identified as potential independent risk factors for HO formation [11,35]. The worker's compensation and non-worker's compensation cohorts in this study did have a significantly different percent of male patients and this could be a further confounder for the study.…”

Section: Discussionmentioning

confidence: 99%

Elbow Heterotopic Ossification Excision in Patients with Worker’s Compensation Claims

2018

J Orthopedics Rheumatol

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The effect of worker's compensation claims following the surgical management of symptomatic heterotopic ossification (HO) about the elbow has not previously been evaluated. The purpose of this study is to report on a consecutive series of patients with HO about the elbow, and to compare the results of surgical treatment and a standardized postoperative rehabilitation regimen, with regards to the presence of a worker's compensation claim. A retrospective review of all patients treated operatively for HO of the elbow at a single institution was performed. Forty-six elbows with HO treated surgically were identified. Seventeen of the 46 elbows (37%) had workers' compensation claims at the time of surgery. Other than gender (p=0.007), there was no statistical difference in patient demographics or medical history. There was no statistical difference in postoperative flexion-extension arc between the two groups (p>0.05). There was a 17% (8/46) postoperative complication rate, however there was no difference in frequency of complications between groups (Worker's Comp: 18% vs. Non-Worker's Comp: 17%; p=0.97). Surgical management combined with postoperative HO prophylaxis and a regimented rehabilitation program is an effective treatment for patients with heterotopic ossification of the elbow and workers compensation claims did not adversely affect the postoperative range of motion arc or complications.

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“…Çalışmamızda HO sıklığı %30 olarak saptandı. Literatürde bu oran %1 ile %70 arasında değişmektedir 20,21 . Cerrahi yaklaşım ile HO gelişimi arasındaki ilişkiyi değerlendiren birçok yayında, anterolateral yaklaşımda posterolateral yaklaşıma oranla daha fazla HO görüldüğü bildirilmektedir 22,23 .…”

Section: Radyolojik Değerlendirmeunclassified

Clinical outcomes of cementless total hip replacement in coxarthrosis

Bağır

Yılmaz

2020

Cukurova Medical Journal

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The outcomes of cemented, cementless and hybrid fixation options in total hip replacement are still controversial. The aim of our study is to evaluate the clinical and radiological results of our cementless total hip replacement cases compared with the literature. Materials and Methods: We evaluated 80 patients' 95 cementless total hip arthroplasties retrospectively. The minmum follow up periodwas 12 months. We used the Harris Hip Score (HHS) for clinical evaluation. We evaluated malposition, aseptic loosening, heterotopic ossification, dislocation and other complications by direct radiography. Results: Forty seven (58.7%) of the patients were female and 33 were male (41.3%). Mean age of the patients was 52.312.8 years. Thirtysix (45%) of the patients were operated in the right hip, 29 (36%) of the patients were operated in the left hip and 15 (18.7%) of the patients were operated bilaterally. Posterolateral incision was used in 74 (77.9%) patients and posterolateral incision was used in 21 (22.1%) patients. Mean follow up was 3818.8 months. Total Harris hip scores of the patients before and after surgery were 28.5210.93 and 87.097.03, respectively. There was acetabular malposition in 12 patients. Eight patients had intraoperative fractures. Conclusion: Cementless total hip arthroplasty provided good clinical outcomes in Harris Hip Score evaluation in short to-medium-term. Rigid cementless fixation in early period can be achieved but, caution is advised against intraoperative fracture and acetabular component malposition.

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Ethnic differences in heterotopic ossification following total hip arthroplasty

Abstract: African Americans are at an increased risk for developing heterotopic ossification and thus may benefit from HO prophylaxis. Cite this article: Bone Joint J 2016;98-B:761-6.

Cited by 20 publications

References 48 publications

Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification

Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification

Elbow Heterotopic Ossification Excision in Patients with Worker’s Compensation Claims

Clinical outcomes of cementless total hip replacement in coxarthrosis

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