Ethnic Differences in Male Lupus

Carbone, Laura D; Lohr, Kristine M.

doi:10.1097/00124743-200208000-00020

Cited by 10 publications

(21 citation statements)

References 9 publications

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“…During the disease course, type IV lupus nephritis was significantly more common in men in our study.Higher prevalence of renal involvement in men has been reported by several authors . In accordance with previous studies, diffuse proliferative glomerulonephritis was the dominant histological finding in male lupus nephritis …”

Section: Discussionsupporting

confidence: 90%

“…The results of previous studies have revealed that male patients develop the typical clinical manifestations of lupus as in female patients; however, certain key clinical manifestations may be different . There is inconsistency about the type of differences in several studies, which may be due to the low number of patients in most of the past surveys, variable duration of follow up and different pattern of disease in different ethnicities …”

Section: Introductionmentioning

confidence: 99%

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Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

et al. 2014

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Aim: To investigate the impact of gender on expression of systemic lupus erythematosus (SLE) in a cohort of 2355 SLE patients as one of the largest series of cases among the present reports.Method: In this retrospective study we used medical records of all patients (239 male and 2116 female) of the SLE registry of Rheumatology Research Center (RRC), Tehran University of Medical science (TUMS), Iran. Both clinical and paraclinical manifestations of SLE patients have been registered in this database since 1976 and updated during their follow-up. Chi-square test was used to compare the clinical and paraclinical manifestations in men and women at disease onset and during the disease course. We used logistic regression to compute odds ratios with 95% confidence intervals. A P-value < 0.05 was considered as statistically significant.Results: Mean age at disease onset was 25 AE 11.8 and 24.5 AE 10.3 years in men and women, respectively (P = 0.48). Comparison of clinical and immunological manifestations showed that male patients had a higher prevalence of mucocutaneous (43.5% vs. 33.7%, P = 0.005) and a lower prevalence of musculoskeletal symptoms (44% vs. 54.7%, P = 0.003) as the initial manifestation. During the disease course, discoid rash (25.9% vs. 13%, P = 0.000) and type IV lupus nephritis (23.4% vs. 18.1%, P = 0.03) were significantly more common, whereas arthritis (61.1% vs. 71.7%, P = 0.01) and leukopenia (28.5% vs. 35.8%, P = 0.024) were significantly less common in men.Conclusion: This study reveals gender influence on some manifestations of SLE. Considering sex differences is recommended in diagnostic and therapeutic features of the disease.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

et al. 2014

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“…As noted above, renal damage is of prime concern for severe and important organ damage in male lupus. A higher risk of developing chronic renal failure in male SLE has been reported in several studies (32,33,36). In a recent report from the LUMINA (Lupus in Minorities: NAture vs. nurture) study group, damage (quantified by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index-SLICC) was found more common and of higher magnitude in male patients (18).…”

Section: Outcome In Male Slementioning

confidence: 81%

“…Many studies demonstrated a higher prevalence of renal disease in male patients compared to female patients, in both adult and pediatric SLE populations (7,8,14,(16)(17)(18)(28)(29)(30)(31)(32)(33). In some studies, diffuse proliferative glomerulonephritis was observed as the dominant histological finding on renal biopsy in males (33)(34)(35)(36). Some authors even observed an increased risk of renal failure in males (32,33,36).…”

mentioning

confidence: 99%

Review: Male systemic lupus erythematosus: a review of sex disparities in this disease

Wallace

Ishimori

et al. 2009

Lupus

163

159

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Although males with systemic lupus erythematosus (SLE) represent 4-22% of all SLE patients, it may not be appropriate that these cases should be subordinated to females with SLE in terms of most health-related issues. Over the past few decades, some distinctive features of male lupus have been observed with regard to genetic and environmental aspects of sex differences, clinical features, and outcome. In addition, recent insights into sex disparities in this disease have brought forth a few plausible and novel pathogenetic hypotheses. This review discusses these findings and sex disparities in SLE that appear to be especially noteworthy and pertinent to our understanding of male SLE.

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“…Females and males show distinct immune characteristics, and it is considered that female sex hormones cause enhanced immune responses 3 . In previous studies, different aspects of lupus in both sexes in different geographical regions were studied 15 16 . The prevalence of SLE in Iran has been reported to be 40/100,000 17 , and more severe symptoms have been observed in Iranian lupus patients compared to European Caucasians 18 .…”

mentioning

confidence: 99%

Clinical & immunological characteristics in systemic lupus erythematosus patients

Rastin¹,

Mahmoudi²,

Sahebari³

et al. 2017

Indian Journal of Medical Research

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Background & objectives:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which affects females more than males. Gender affects the manifestations of SLE and men with lupus show more severe symptoms and worse prognosis. This study was aimed to compare clinical and immunological features in female and male lupus patients in Iran.Methods:Demographic, clinical and laboratory data from 78 women and 20 men with lupus were collected. Autoantibodies (against nRNP, Sm, SSA, SSB, Ro-52, CENP, Jo-1, Scl-70, nucleosome, anti-dsDNA, histone and Rib-p protein) were determined using immunoblotting technique.Results:Men with lupus had less anti-SSA (21.1 vs 48.1%) and anti-Ro52 (10.5 vs 44.3%) antibodies when compared to women and none of the male patients had anti-SSB antibodies. Kidney damage was more frequent in men (68.4% in men vs 36.7% in women). In men with kidney involvement, anti-dsDNA increased significantly (84.6 vs 20.0%) in comparison to males without nephritis. Anti-SSA (7.7 vs 50.0%) and anti-nRNP (0.0 vs 33.8%) on the other hand, decreased. Women with renal involvement had no anti-SSB antibodies.Interpretation & conclusions:In male patients, SLE appeared with more severe features, and kidney damage was more frequent in males. The frequency of some autoantibodies was different between females and males. In males with kidney damage anti-dsDNA increased significantly, while anti-SSA and anti-nRNP decreased. Anti-SSB was not detected in males and females with nephritis.

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Ethnic Differences in Male Lupus

Cited by 10 publications

References 9 publications

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

Clinical and immunological pattern of systemic lupus erythematosus in men in a cohort of 2355 patients

Review: Male systemic lupus erythematosus: a review of sex disparities in this disease

Clinical & immunological characteristics in systemic lupus erythematosus patients

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