Ethnic variation in the HER-2 codon 655 genetic polymorphism previously associated with breast cancer

Ameyaw, Margaret‐Mary; Tayeb, Mohammed T.; Thornton, Nadia; Folayan, Gbolahan; Tariq, Mohd; Mobarek, Abeer; Evans, David A.; Ofori‐Adjei, David; McLeod, Howard L.

doi:10.1007/s100380200019

Cited by 49 publications

(18 citation statements)

References 27 publications

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“…The results of present study showed overall improvement in the knowledge of dispensers regarding storage of drugs, prescription terminologies and status of drugs at community pharmacies after the training. Similar impact of educational intervention has been reported in knowledge of dispensers who were subjected to training 11,16,19,20. Interventions can improve the knowledge and practices of dispensers working at community pharmacies.…”

Section: Discussionsupporting

confidence: 74%

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Impact of educational intervention on knowledge of dispensers working at community pharmacies in Pakistan

Hussain

Ibrahim

Malik

2013

Pharmacy Practice (Internet)

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IMPACTO DE UNA INTERVENCIÓN EDUCATIVA SOBRE EL CONOCIMIENTO DE LOS DISPENSADORES QUE TRABAJAN EN FARMACIAS COMUNITARIAS EN PAKISTÁN RESUMENObjetivo: Evaluar el impacto de la formación de los dispensadores sobre el conocimiento de estos dispensadores que trabajan en farmacias comunitarias en relación a la temperatura de almacenamiento, terminologías de medicamentos de prescripción y status de los medicamentos en Islamabad, Pakistán. Métodos: Se diseñó e implementó un estudio de intervención controlado, aleatorizado y ciego. Antes de la implantación de la intervención, se realizó un estudio de base para evaluar el conocimiento de los dispensadores que trabajaban en farmacias comunitarias. La población en estudio incluyó todos los establecimientos de farmacia comunitaria de Islamabad. Las farmacias de Islamabad que fueron visitadas en la fase preintervención (n=118) fueron divididas en dos áreas geográficas: A (intervención) and B (control). Treinta farmacias fueron aleatoriamente seleccionadas en cada región. Con la experiencia del estudio basal, se diseñó una intervención educativa para mejorar el conocimiento de los dispensadores que trabajan en farmacias comunitarias en Pakistán. Resultados: Se observó una diferencia significativa pre-y post-intervención en el conocimiento general de los dispensadores en el grupo intervención. Después de la formación, se mejoró el conocimiento de los dispensadores en relación a almacenamiento de medicamentos, terminología de medicamentos de prescripción y status de los medicamentos. Por el contrario, no se observó diferencia significativa pre-post en el grupo control. Conclusión: El estudio ha remarcado que, a través de intervenciones adecuadas, se pueden conseguir mejoras en el conocimiento de los dispensadores que trabajan en farmacias comunitarias. Pero, los resultados de las intervenciones solo pueden ser sostenibles mediante una monitorización continua y un aumento de la formación.

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Section: Discussionsupporting

confidence: 74%

“…It involves focused small group training, one on one educational training, peer-educators, in-service training, moderated group discussion, large group training, feedback or peer review 11,12. Persuasive educational intervention enables behavior change by addressing barriers to change 13,14.…”

Section: Introductionmentioning

confidence: 99%

Impact of educational intervention on knowledge of dispensers working at community pharmacies in Pakistan

Hussain

Ibrahim

Malik

2013

Pharmacy Practice (Internet)

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“…Oncogenic amplification of HER‐2/neu gene occurs in about 30% of early‐stage breast cancers, and significant correlation has been reported between HER‐2/neu overexpression and conditions, such as steroid hormone receptor‐negative status, higher histological grades, higher rate of proliferation, reduced response to chemotherapy and hormone therapy, and reduced survival of breast cancer patients 2 , 11 . The isoleucine to valine polymorphism of codon 655 of the HER‐2/neu gene has been repeatedly investigated for an association with breast cancer 23–43 and other solid tumors 36 , 42 . These studies show either increased risk, decreased effect, or no overall association, possibly depending on ethnic variation 24 .…”

Section: Discussionmentioning

confidence: 99%

HER‐2/neu Ile655Val Polymorphism and the Risk of Breast Cancer

Siddig

Mohamed

Kamal

et al. 2008

Annals of the New York Academy of Sciences

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Genetic alterations of the proto-oncogene human epidermal growth factor receptor (HER-2/neu) have been shown to induce malignant transformation and metastasis. Genotyping studies have addressed the association of codon 655 isoleucine to valine polymorphism located in the transmembrane coding region and the risk of breast cancer, but the results are inconsistent. In this study, we investigated the association of HER-2/neu Ile655Val polymorphism and the risk of breast cancer in a Sudanese population. In addition, the joint effects of HER-2/neu variants and our previously reported ESR1C325G polymorphism were tested for their association with breast cancer risk. Candidate single nucleotide polymorphism (SNP) in HER-2/neu Ile655Val [db SNP rs1136200] was genotyped in breast cancer patients and in healthy controls that were randomly selected from the same age group as the patients. Genotyping was performed using a high-throughput allelic discrimination method using real-time PCR, and data on clinical features and demographic details were collected. Associations between genotype and breast cancer were assessed by means of logistic regression. The prevalence of Val/Val genotype was similar in patients of breast cancer and control subjects. In comparison with the Ile/Ile genotype, the Ile/Val had a borderline significantly (P= 0.06) higher risk of breast cancer (OR = 2.95, 95% CI: 0.97-8.96). Regarding the genotypic and allelic frequencies stratified by age and menopausal status, there were no significant associations. A significantly higher risk of breast cancer was observed among homozygous carriers of ESR1325 CC genotype and heterozygous carriers of HER-2/neu655 Ile/Val genotype (P= 0.05; adjusted OR = 4.9, 95% CI: 1.0-24). The association of HER-2/neu Ile655Val polymorphism and the risk of breast cancer was borderline significant with the heterozygous carrier being at higher risk. However, the frequency of different polymorphic variants varies with ethnicity. The results of this study suggest that a significant gene-gene interaction between ESR1325C (previously reported) and HER-2/neu Ile655Val variants may jointly contribute to a higher risk of breast cancer.

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“…Amplified HPV fragments were typed on the basis of the restriction fragment length polymorphism among HPVs (28) . L1-PCR can detect 22 registered low-risk (6,11,34,40,42,43,44) and high-risk (16,18,31,33,35,39,45,51,52,56,58,59, 66, 68, 69) HPV types.…”

Section: Hpv Typingmentioning

confidence: 99%

HER-2 codon 655 polymorphism in cervical carcinogenesis

Ueda

Hung

Saito

et al. 2006

Int J Gynecol Cancer

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HER-2 codon 655 polymorphism together with human papillomavirus (HPV) types were examined in a total of 279 cervical smear samples. Forty-nine patients with high-grade squamous intraepithelial lesion had higher frequency of high-risk HPV than 167 patients with low-grade squamous intraepithelial lesion and 63 controls. There was no statistical difference in the frequencies of HER-2 Ile/Ile, Ile/Val, and Val/Val genotypes between squamous intraepithelial lesions (SILs) and controls. When the Ile/Ile genotype was compared to the Ile/Val + Val/Val genotypes, there was also no statistical difference in the genotype prevalence between SILs and controls either in 91 or 188 patients with or without high-risk HPV, respectively. These results suggest that the HER-2 polymorphism at codon 655 in cervical cell samples is unlikely to be associated with HPV status and the onset of cervical cancer in a Japanese population.

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Ethnic variation in the HER-2 codon 655 genetic polymorphism previously associated with breast cancer

Cited by 49 publications

References 27 publications

Impact of educational intervention on knowledge of dispensers working at community pharmacies in Pakistan

Impact of educational intervention on knowledge of dispensers working at community pharmacies in Pakistan

HER‐2/neu Ile655Val Polymorphism and the Risk of Breast Cancer

HER-2 codon 655 polymorphism in cervical carcinogenesis

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