Ethnomedicinal Wisdom

Mahapatra, Ananya Das; Bhowmik, Priyanka; Banerjee, Anwesha; Das, Apurba; Ojha, Durbadal; Chattopadhyay, Debprasad

doi:10.1016/b978-0-12-814619-4.00003-3

Cited by 20 publications

(17 citation statements)

References 106 publications

(71 reference statements)

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“…Empirical data on SARS-CoV treatments are scarce (Wong and Yuen 2008), and the majority of viral diseases do not have targeted drugs or vaccines (Mahapatra et al 2019). Although the ongoing SARS-CoV-2 global pandemic should remind scientists that current options for treating life-threatening zoonotic coronavirus infections are very limited (Wu et al 2020), medicinal plants offer a strong pipeline for the discovery of novel lead compounds that can be converted into new drugs to treat COVID-19.…”

Section: Perspective On Future Directionsmentioning

confidence: 99%

“…Potential anti-coronavirus therapies can be divided into two categories depending on their target: those that act on the human immune system or human cells, and those that interfere with the coronavirus itself (Wu et al 2020). The unmet need for pharmacologically potent and safe antivirals ought to be fulfilled by thinking out of the box and indigenous knowledge of medicinal plants may be a masterstroke against deadly infectious diseases such as COVID-19 (Mahapatra et al 2019). Vellingiri et al (2020) postulated that medicinal plants are potential sources of drugs for the treatment of COVID-19.…”

Section: Perspective On Future Directionsmentioning

confidence: 99%

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Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Chinsembu

2020

Rev. Bras. Farmacogn.

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Current challenges to the treatment of coronavirus disease 2019 should open new prospects in the search for novel drugs from medicinal plants and other natural products. This paper provides details of natural agents that inhibit human coronavirus entry into cells, general replication, and specific chymotrypsin-like protease (3CL pro)-mediated replication. Medicinal plants, fungi, and marine organisms as remedies for human coronaviruses in China, Lebanon, Malaysia, Singapore, and South Africa are described. Common species include Alnus japonica (Thunb.

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Section: Perspective On Future Directionsmentioning

confidence: 99%

Section: Perspective On Future Directionsmentioning

confidence: 99%

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Chinsembu

2020

Rev. Bras. Farmacogn.

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“…Based on these experts, it can be concluded that supervision is the leadership activities of each organization that makes sure that the work is carried out in accordance with the plans set or the desired results by supervising the work carried out by subordinates (Mahapatra et al, 2019).…”

Section: B Monitoring Theorymentioning

confidence: 99%

Sak Uwong Sak Uwit for Environmental Protection Based on Local Wisdom: An Environmental Law Reform in Indonesia

Kusumo¹,

Kurnianto²

2019

JLLR

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The research is examines the local wisdom values of Sak Uwong Sak Uwit as environmental protection in the context of local regulation. After the issuance of the regulation, of course it must be understood how the implementation of the regulation and how to supervise the implementation of this policy in Pegandon Village, Pegandon District, Kendal Regency. This research is a sociological juridical research with a qualitative approach, with research locations in Kendal District Community and Village Empowerment Agency and Pegandon Village. The technique of checking the validity of the data uses source triangulation and technique triangulation techniques. Analysis of the data used is an interactive analysis model. This study concluded that, first, in Pegandon Village running the program of Sak Uwong Sak Uwit (SUSU) or One Man One Tree was only at the beginning of the year, because of its lack of approval by the people who had to bear the burden of costs, non-existent planting land and management of unclear results. Then, the second shows that the lack of seriousness of the Regional Government in terms of guidance and supervision of this program has an impact on the Implementation of the Sak Uwong Sak Uwit (SUSU) Local Regulation.

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“…Since ages, plants have been used as a source of therapeutics in diverse ethnomedicinal practices. Many ethnomedicinal plant extracts and phytocompounds are known to modulate host immune responses (33) and may exert antimicrobial and antiviral effects (34). A variety of plant compounds including alkaloids, coumarins, essential oils, flavonoids, polyphenols, phytosterols, proteins, peptides, saponins, and tannins play diverse roles in the human system.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico Approach

et al. 2021

Self Cite

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SARS-CoV-2 infection across the world has led to immense turbulence in the treatment modality, thus demanding a swift drug discovery process. Spike protein of SARS-CoV-2 binds to ACE2 receptor of human to initiate host invasion. Plethora of studies demonstrate the inhibition of Spike-ACE2 interactions to impair infection. The ancient Indian traditional medicine has been of great interest of Virologists worldwide to decipher potential antivirals. Hence, in this study, phytochemicals (1,952 compounds) from eight potential medicinal plants used in Indian traditional medicine were meticulously collated, based on their usage in respiratory disorders, along with immunomodulatory and anti-viral potential from contemporary literature. Further, these compounds were virtually screened against Receptor Binding Domain (RBD) of Spike protein. The potential compounds from each plant were prioritized based on the binding affinity, key hotspot interactions at ACE2 binding region and glycosylation sites. Finally, the potential hits in complex with spike protein were subjected to Molecular Dynamics simulation (450 ns), to infer the stability of complex formation. Among the compounds screened, Tellimagrandin-II (binding energy of −8.2 kcal/mol and binding free energy of −32.08 kcal/mol) from Syzygium aromaticum L. and O-Demethyl-demethoxy-curcumin (binding energy of −8.0 kcal/mol and binding free energy of −12.48 kcal/mol) from Curcuma longa L. were found to be highly potential due to their higher binding affinity and significant binding free energy (MM-PBSA), along with favorable ADMET properties and stable intermolecular interactions with hotspots (including the ASN343 glycosylation site). The proposed hits are highly promising, as these are resultant of stringent in silico checkpoints, traditionally used, and are documented through contemporary literature. Hence, could serve as promising leads for subsequent experimental validations.

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Ethnomedicinal Wisdom

Cited by 20 publications

References 106 publications

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Sak Uwong Sak Uwit for Environmental Protection Based on Local Wisdom: An Environmental Law Reform in Indonesia

Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico Approach

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