Ethnopharmacology of Artemisia annua L.: A Review

Sadiq, Alia; Hayat, Muhammad Qasim; Ashraf, Muhammad

doi:10.1007/978-3-642-41027-7_2

Cited by 29 publications

(27 citation statements)

References 32 publications

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“…A. annua seed extracts can be used to treat eye diseases [29,82]. The plant is traditionally used in the form of infusions, aqueous extracts, and tinctures from the dried herb [17,83].…”

Section: Applications In Traditional Asian Medicinementioning

confidence: 99%

Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications

et al. 2021

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Artemisia annua (annual mugwort) is a species that has long been used in traditional Asian medicine, mainly Chinese and Hindu. The species is widespread and known as a medicinal plant not only in Asia but also in Europe, in both Americas, and Australia. The species has become a subject of particular interest due to the 2015 Nobel Prize awarded for detecting the sesquiterpene lactone artemisinin in it and proving its antimalarial activities. The raw materials obtained from this species are Artemisiae annuae folium and Artemisiae annuae herba. The leaves are a raw material in the Chinese Pharmacopoeia and Vietnamese Pharmacopoeia. Both raw materials are in the International Pharmacopoeia published by the WHO. The main components of these raw materials are mainly specific sesquiterpene lactones, essential oil, flavonoids, coumarins, and phenolic acids. In traditional Asian medicine, the species is used, for example, in the treatment of jaundice and bacterial dysentery, as an antipyretic agent in malaria and tuberculosis, in the treatment of wounds and haemorrhoids, and in viral, bacterial, and autoimmune diseases. Professional pharmacological studies conducted today have confirmed its known traditional applications and explain previously unknown mechanisms of its biological action and have also found evidence of new directions of biological activity, including, among others, anti-inflammatory, analgesic, antioxidant, antitumour, and nephroprotective activities. The species is of growing importance in the cosmetics industry.

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“…A. annua seed extracts can be used to treat eye diseases [29,82]. The plant is traditionally used in the form of infusions, aqueous extracts, and tinctures from the dried herb [17,83].…”

Section: Applications In Traditional Asian Medicinementioning

confidence: 99%

Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications

et al. 2021

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“…The effects of artemisinin have been studied in many diseases, such as cancer and infectious or parasitic diseases, and artemisinin is used as a combination therapy against drug-resistant malaria (Naeem et al, 2014;Sadiq et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Influence of dietary artemisinin supplementation on productive performance and haematological parameters of broiler chickens

et al. 2017

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-In the present study, we aimed to assess the toxicity of artemisinin on the haematological system and its effect on the productive performance of broiler chickens. Eighteen-day-old chickens were randomly divided into four groups of 30 chickens (three replicates of 10 broilers/group): control group and three experimental groups: ART5 -diet with 5 ppm of artemisinin; ART50 -diet with 50 ppm of artemisinin; and ART500 -diet with 500 ppm of artemisinin. Artemisinin enhanced the productive performances of broiler chickens at the lowest concentration (5 ppm), but at the highest concentration (500 ppm), it negatively affected weight gain and the feed conversion ratio. The performance characteristics of the chickens whose diets were supplemented with 50 ppm artemisinin were similar to those of the control group. Additionally, 5 ppm artemisinin in feed did not significantly affect the haematological parameters of the chickens, but 50 and 500 ppm artemisinin induced a gradual decline of the total leukocytes, lymphopenia, monocytosis, and eosinopenia, and the highest concentration caused anaemia. Artemisinin at a low concentration could be used as a feed additive in the poultry industry to improve organic broiler production performance with no serious side effects.

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“…Factor XII activation was assayed [ 6 ]. A volume of 70 µL of purified human factor XII (0.14 mg/mL) and 70 µL of extracts (10 mg/mL) were incubated for 5 h and then the mixtures were resolved by SDS-PAGE and stained with silver.…”

Section: Methodsmentioning

confidence: 99%

“…The hemostatic components and mechanisms of action in some of these herbs have been investigated using the mouse bleeding model [ 1 - 5 ]. Hemostyptics are specific hemostatic agents that retard or stop bleeding by causing blood vessels to contract or by accelerating blood clotting when externally applied [ 3 , 6 , 7 ]. The hemostatic activities of herbal hemostyptics are often due to mechanisms such as tannin astringency [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Screening for hemostatic activities of popular Chinese medicinal herbs in vitro

Ohkura¹,

Yokouchi²,

Mimura³

et al. 2015

J Intercult Ethnopharmacol

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Aims:This study aimed to identify new hemostyptics by assessing the coagulation enhancing activity of 114 Chinese herbal extracts in vitro.Methods:Herbs were boiled in water for 30 min, filtered and then lyophilized filtrates (10 mg/mL) were dissolved in water. Coagulation was assayed as prothrombin time (PT). Plasma diluted in saline was incubated with each extract for 5 min and then PT reagent was added, followed by CaCl2 solution and the time taken to form clots was measured. Extracts that decreased coagulation time were regarded as containing active compounds. The abilities of extracts to activate Factor XII were assessed and the activated form of factor XII (XIIa) was resolved by SDS-PAGE and visualized by silver staining.Results:Coagulation time was obviously shortened by extracts of Alpinia Rhizome, Areca, Artemisia Leaf, Cassia Bark, Danshen Root, Ephedra Herb, Epimedium Herb, Forsythia Fruit, Great Burdock Achene, Moutan Bark, Perilla Herb, Red Paeony Root, Schizonepeta Spike, Senticosus Rhizome, Sweet Annie, Uncaria Thorn and Zanthoxylum Peel. Factor XII was obviously activated by extracts of Artemisia Leaf and Great Burdock Achene, and slightly by Perilla herb.Conclusion:Some popular Chinese medicinal herbs have potential as hemostatic agents and could thus be develope as new strategies for the treatment and prevention of bleeding.

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Ethnopharmacology of Artemisia annua L.: A Review

Cited by 29 publications

References 32 publications

Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications

Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications

Influence of dietary artemisinin supplementation on productive performance and haematological parameters of broiler chickens

Screening for hemostatic activities of popular Chinese medicinal herbs in vitro

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