Ethyl Chloroformate as a Derivatizing Reagent for the Gas Chromatographic Determination of Isoniazid and Hydrazine in Pharmaceutical Preparations

Simple and sensitive determination of hydrazine in drinking water by ultra-high-performance liquid chromatography–tandem mass spectrometry after derivatization with naphthalene-2,3-dialdehyde

“…The NDA reaction conditions with hydrazine were very similar to the pH values [24,34,35], reaction temperatures and times [34,35] employed in previous studies. …”

“…Specifically, gas chromatography (GC) and high performance liquid chromatography (HPLC) are typically used for the determination of hydrazine in water. GC methods for hydrazine have been developed using electron capture detection [21], nitrogen-selective detection [22,23], flame-ionization detection [24], mass spectrometry (MS) [23,[25][26][27], and tandem mass spectrometry (MS/MS) [19,28]. HPLC methods have also been developed using diode array detection [20,[29][30][31] and fluorescence detection [32][33][34][35].…”

“…In GC, derivatization reagents, such as acetone [19], pentafluorobenzaldehyde [21,23], benzaldehyde [22], ethyl chloroformate [24], n-hexyl chloroformate [25], octafluoropentylchloroformate [26], ortho-phthalaldehyde (OPA) [27], and propyl chloroformate [28], have been used. However, these GC methods require additional extraction and concentration steps after derivatization.…”

Nano Formulation Analysis: Analytical Method Development of Isoniazid and Simultaneous Estimation of Anti-Tubercular Drugs Isoniazid and Rifampicin by Rp-HPLC

“…To determine polar compounds various analytical methods exists specifically for INH in literature [6]. Various other methods also have been described for determination and quantification of INH, such as H-point standard addition method [7], selective adsorption using a piezoelectric sensor [8], voltammetric method [9], amperometric method [10], chromatographic methods [11][12][13][14] (HPLC, GC and HPTLC), titrimetric methods [15], and chemiluminescence [16]. In addition, several (HPLC) methods for the simultaneous determination of rifampicin (RIF), INH, and pyrazinamide (PZA) in a fixed-dose combination [17] simultaneous analysis of RIF, INH and PZA in 0.1 M hydrochloric acid dissolution medium and in simulated gastric fluid [18], quantitative determination of INH in plasma, brain, liver and kidney samples and in solid lipid nanoparticles [19].…”

GC Analysis of Amino Acids Using Trifluoroacetylacetone and Ethyl Chloroformate as Derivatizing Reagents in Skin Samples of Psoriatic and Arsenicosis Patients

“…The sensitivities of the determinations have been further enhanced by the use of different fluorosubstituted chloroformates and using mass-spectrometric detection devices [39,[41][42][43]. Trifluoroacetylacetone (FAA) reacts with primary amino containing compounds to form the derivatives amiable to GC [44][45][46][47]. The amino acids containing primary amino group react with FAA to form derivatives, which elute from GC column with enhanced sensitivity due to the increase in carbon chain length.…”