Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices

Genina, Natalja; Holländer, Jenny; Jukarainen, Harri; Mäkilä, Ermei; Salonen, Jarno; Sandler, Niklas

doi:10.1016/j.ejps.2015.11.005

Cited by 243 publications

(121 citation statements)

References 20 publications

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“…46 On the other hand, ethyl vinyl acetate has been used as a novel drug carrier for a 3D printed T-shaped intrauterine drug delivery system for indomethacin. 47 In a similar study, polycaprolactone has also been used to deliver indomethacin in a controlled-release manner in a 3D printed polycaprolactone-based implantable prototype of Tshaped intrauterine system. 48 In consideration of the wide variety of polymers that can potentially be used for drug delivery systems, we encourage future studies to also explore these polymers for the scaffold designs of drugs, such as carbamazepine.…”

Section: Limitationsmentioning

confidence: 98%

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Lim

Chia

Kang

et al. 2016

Journal of Pharmaceutical Sciences

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Section: Limitationsmentioning

confidence: 98%

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Lim

Chia

Kang

et al. 2016

Journal of Pharmaceutical Sciences

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“…Furthermore, EA Clark et al produced tablets consisting of a cross‐linked PEGDA hydrogel matrix containing the drug and photoinitiated in a low oxygen environment by using an aqueous solution of Irgacure 2959. Furthermore, the versatility of 3DP technologies in the development of drug delivery systems includes gastro‐floating tablets in gastro‐retentive drug delivery systems, personalized oral medicine, medical devices, and wound dressings …”

Section: Polymersmentioning

confidence: 99%

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

Oderinde

Kang

et al. 2018

Polymers for Advanced Techs

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Three‐dimensional printing (3DP) technologies, which are sets of powerful deposition methods employed to fabricate 3D objects with materials in the fields of material sciences and engineering, biomedical and biocompatible structural components, automotive, aviation, and polymers, among others, are currently rapidly developing manufacturing technologies. The methods have significant advantages, which include designing flexibility, enhanced geometrical freedom, low cost, and net shape manufacture, among others, over the traditional “subtractive” method. This review highlights the major 3D printing techniques, especially in the fields of advanced polymeric material fabrication and engineering, as well as the synergy in the incorporation of different types of polymeric materials and composites in a process that will lead to an enhancement of dimensional accuracy for 3D technologies. Furthermore, composite ink systems especially polymer‐based and hydrogel‐based in tissue engineering applications are also discussed.

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“…Unfortunately, PLA and ABS still do not yet fully meet realistic requirements, since PLA is an eco‐friendly polymer that has a high printing temperature and ABS exhibits great mechanical properties but has biodegradability issues; these flaws are the main factors that restrict the application of PLA and ABS in many fields. Recently, some newly developed plastics have been applied to FDM, such as high‐impact polystyrene (HIPS), polycarbonate, polyamide, polyether ether ketone, ethylene vinyl acetate, polypropylene, and their blends, but the low applicability, nondegradable nature, and high printing temperature of these plastics still suppress their printability. Therefore, the preparation of new printing materials with biodegradability, wide applicability, and low printing temperature has become a popular topic.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Rheological and Mechanical Properties of Poly(butylene succinate)/Talc Composites for Material Extrusion Additive Manufacturing

Zhou

Xia²,

Liu

et al. 2019

Macro Materials & Eng

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In this paper, poly(butylene succinate) (PBS) with a low melting point and a similar performance to polyethylene is employed as a printing material; talc is introduced into the matrix to enhance the melt strength of pure PBS during printing. The PBS/talc composite 3D printing filament is prepared by melt extrusion, and the thermal, mechanical, morphological, and rheological properties of the composites are investigated. The results show that the addition of talc to PBS leads to an increase in crystallization temperature. In addition, the tensile and flexural strengths of the injection‐molded specimens increase when the talc concentration increases. However, the mechanical properties of the printed specimens exhibit an opposite variation trend due to their distinct forming process. The printing temperature is 135 °C, which is far lower than those of commercial grade polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS) printing filaments. Scanning electron microscopy (SEM) images show that increasing the talc concentration creates better printed formability and well‐organized fracture surface structures. By comparing printed fishbones, the results suggest that the presence of talc leads to a good printing performance with the composite. Furthermore, the rheological results reveal that η*, G′, and G″ are enhanced by the addition of talc.

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Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices

Cited by 243 publications

References 20 publications

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

Preparation and Rheological and Mechanical Properties of Poly(butylene succinate)/Talc Composites for Material Extrusion Additive Manufacturing

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