Ethylenediamine Functionalized Cellulose Acetate [CAEDA] Nanosized Solid Base Catalyst in the Synthesis of 2‐Amino‐4H‐Chromenes and 5‐Substituted‐1H‐Tetrazoles

Abstract

A series of 2-amino-4H-chromenes by combining dimedone, different substituted aromatic aldehydes and malononitrile and 5-substituted-1H-tetrazoles by combining variable aldehydes, hydroxylamine hydrochloride and sodium azide have been efficiently synthesized in presence of ethylenediamine functionalized cellulose acetate as a solid base catalyst i.e Cellulose acetate[1,2-ethylenediamine][CAEDA]. This catalyst is low-cost, non-toxic, unexplored, easily available, reusable, eco-friendly in nature. This synthesized solid base catalyst has been characterized by fourier transform infrared spectroscopy (FTIR), themogravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) spectroscopic techniques. The new catalytic method exhibits some noteworthy advantages such as short reaction time, high yields, easy workup and purification steps, simple preparation method which makes this strategy more useful for the synthesis of chromene and tetrazole derivatives then earlier methods.

High-yield, fast, and green synthesis of acridine derivatives using a Co/C catalyst from rice husks with a microwave-assisted method

“…Research findings indicate that heterocyclic compounds have noteworthy biological characteristics, including anti-cancer, anti-anaphylactic, anti-coagulant, and spasmolytic activities. 29–32…”

CSA@g-C3N4 as a novel, robust and efficient catalyst with excellent performance for the synthesis of 4H-chromenes derivatives

“…Multicomponent reactions (MCR) provision deep knowledge regarding 4H-chromene formation. Furthermore, considerable catalytic schemes have evolved over recent years for the multicomponent synthesis of 4H-chromene derivatives, including RGO-SO 3 H 59 , GO/α-Fe 2 O 3 /CuL 60 , MNPs@Cu 61 , g-C 3 N 4 62 , Pd@g-C 3 N 4 63 , CaMgFe 2 O 4 64 , morpholine 65 , CAEDA 66 , mica/Fe 3 O 4 67 , amino grafted MOFs 68 , DABCO 69 , Fe 3 O 4 @Sal@Cu 70 , Fe 3 O 4 @GO-NH 71 , KCC-1@NH 2 72 , Nano-SiO 2 73 , SnO 2 NPs 74 , Ag 2 O/GO/TiO 2 75 , and borax 76 . Yet, there are several drawbacks concerning plenty of expressed catalysts, including environmental contamination, high price, challenging catalyst removal, and requiring coarse reaction conditions.…”