Etidronic Acid: a New and Efficient Catalyst for the Synthesis of Novel 5-Nitro-3,4-Dihydropyrimidin-2(1H)-Ones

Abstract

A simple, convenient and efficient one-pot cyclocondensation reaction of 1-(2-hydroxyphenyl)-2-nitroethanone, arylaldehydes and urea using etidronic acid to furnish nitro dihydropyrimidine derivatives is described. A new and efficient protocol is developed as a homogenous catalyst for the synthesis of dihydropyrimidines using substituted x-nitro acetophenone. Various bisphosphonic acids were examined to synthesized pyrimidines via multicomponent cyclocondensation reaction. This methodology has the advantage of excellent yields with short reaction time.

Organocatalysis: Key Trends in Green Synthetic Chemistry, Challenges, Scope towards Heterogenization, and Importance from Research and Industrial Point of View

“…Various organocatalysts such as tartaric acid, oxalic acid, citric acid, and lactic acid were found effective in producing Biginelli products [164][165][166][167][168][169][170][171][172]. Because of the "privileged" green nature of this field, it has become an obligation for scientific community and academic institutions to be mindful and teach this branch of catalysis to students and also keep it as a driving force in the generation and dissemination of knowledge in pursuit of efficient synthetic methodologies and processes using organocatalysts.…”

Synthesis of glycolurils and hydantoins by reaction of urea and 1, 2‐dicarbonyl compounds using etidronic acid as a “green catalyst”

“…An efficient approach to the green synthesis of glycoluryls in an aqueous medium using P 4 O 10 as a catalyst, under mild conditions with the possibility of recycling both solvent and catalyst, is reported in Ref. [39] More recently, in a number of works [40][41][42] it was found that etidronic acid (HEDP) proved to be a convenient "green" catalyst in 3-component reactions of the formation of dihydropyrimidones using carbonyl compounds with an active methylene group, urea and aldehydes as under traditional conditions, [40,41] and under microwave synthesis. [42] However, examples of the use of HEDP as a catalyst in the reactions of 1, 2-dicarbonyl compounds with ureas are still not known.…”

Etidronic Acid Promoted Sequential One‐Pot Strategy for the Synthesis of 1H‐Imidazo[1,2‐b]pyrazoles: A Green Catalyst for Groebke‐Blackburn‐Bienaymé Reaction

“…In our previous work we synthesized nitro dihydropyrimidine derivatives via multi‐component reaction in the continuation to this, we were interested in the synthesis of 1 H ‐imidazo[1,2‐ b ]pyrazoles derivatives catalyzed by Etidronic acid as a green catalyst which are easily accessible. The title compounds were prepared via multicomponent GBB reaction in one pot sequential steps by the condensation of 5‐amino‐1 H ‐pyrazole, aldehyde and isocyanide.…”