Etiologic classification of infantile spasms using positron emission/magnetic resonance imaging and the efficacy of adrenocorticotropic hormone therapy

Dang, Haodan; Zou, Li‐Ping; Tian, Jiahe; Liu, Jiajin; Feng, Xiaoyuan; Lin, MingDe; Xu, Baixuan

doi:10.1007/s00259-019-04665-1

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…for infantile epilepsy or infantile spasms and improves etiologic classifications and the predication of therapy efficacy [11,32]. Hybrid PET/MRIidentified 12 subtle hypometabolic areas (with fewer slices and slighter Z-score decreasing) that were overlooked by conventional visual PET analysis.…”

Section: Hybrid Pet/mri Showed Advantage In Soz Precise Localizationmentioning

confidence: 99%

Utility of hybrid PET/MRI multiparametric imaging in navigating SEEG placement in refractory epilepsy

Zhang

Liu

Huang

et al. 2020

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Stereo-electroencephalography (SEEG) implantation before epilepsy surgery is critical for precise localization and complete resection of the seizure onset zone (SOZ). Combined metabolic and morphological imaging using hybrid PET/MRI may provide supportive information for the optimization of the SEEG coverage of brain structures. In this study, we originally imported PET/MRI images into the SEEG positioning system to evaluate the application of PET/MRI in guiding SEEG implantation in refractory epilepsy patients. Materials: Forty-two patients undergoing simultaneous PET/MRI examinations were recruited. All the patients underwent SEEG implantation guided by hybrid PET/MRI and surgical resection or ablation of epileptic lesion. Surgery outcome was assessed using a modified Engel classification one year (13.60 ± 2.49 months) after surgery. Areas of SOZ were identified using hybrid PET/MRI and concordance with SEEG was evaluated. Logistic regression analysis was used to predict the presence of a favorable outcome with the coherence of concordance of PET/MRI and SEEG. Results: Hybrid PET/MRI (including visual PET, MRI, plus MI Neuro) identified SOZ lesions in 38 epilepsy patients (90.47 %). PET/MRI showed the same SOZ localization with SEEG in 29 patients (69.05 %), which was considered to be concordant. The concordance between the PET/MRI and SEEG findings was significantly predictive of a successful surgery outcome (odds ratio = 20.41; 95 % CI = 2.75-151.4, P = 0.003**). Conclusion: Hybrid PET/MRI combined visual PET, multiple sequences MRI and SPM PET helps identify epilepsy lesions particularly in subtle hypometabolic areas. Patients with concordant epileptic lesion localization on PET/ MRI and SEEG demonstrated a more favorable outcome than those with inconsistent localization between modalities.

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Section: Hybrid Pet/mri Showed Advantage In Soz Precise Localizationmentioning

confidence: 99%

Utility of hybrid PET/MRI multiparametric imaging in navigating SEEG placement in refractory epilepsy

Zhang

Liu

Huang

et al. 2020

Seizure

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“…A positron emission tomography (PET) scan is another imaging modality that can be utilized in the evaluation of IS. In intractable IS with negative MRI findings, PET scans can increase the yield of finding focal abnormalities by up to 20% [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Brain Magnetic Resonance Imaging Findings in Infantile Spasms

Muthaffar

2022

Neurology International

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Background: Infantile spasms are an age-specific epileptic disorder. They occur in infancy and early childhood. They can be caused by multiple etiologies. Structural abnormalities represent an important cause of infantile spasms. Brain magnetic resonance imaging (MRI) is one of the integral modalities in the evaluation of this condition. Purpose: The aim of this study is to review and analyze the clinical characteristics and brain MRI findings in a cohort of children diagnosed with infantile spasms. Material and Methods: A cohort of fifty-six children diagnosed with infantile spasms in infancy and early childhood was included. All of them underwent brain MRI for evaluation. The study was conducted in the period from January 2016 to January 2020. Results: Females comprised 57% of the cohort. The mean age for seizure onset was 5.9 months (SD 2.7). Forty-one patients (73%) had active epilepsy, and 51% were diagnosed with global developmental delay. Consanguinity was present in 59% of the cohort. Most of the follow-up MRIs showed structural abnormalities (84%). Hypoxia was reported in 17% of MRIs. Malformations of cortical development were seen in five patients. Brain MRI findings were normal in 16% of patients, and delayed myelination was seen in nineteen patients. Most of the children with active epilepsy (64%) and developmental delay (82%) had an abnormal brain MRI. It was noticed that abnormal second brain MRIs were more likely to be associated with active epilepsy and developmental delay (p = 0.05). Conclusions: Brain MRI is an integral part of infantile spasms’ clinical evaluation. Infantile spasms and abnormal brain MRI can be associated with active epilepsy and global developmental delay.

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Etiologic classification of infantile spasms using positron emission/magnetic resonance imaging and the efficacy of adrenocorticotropic hormone therapy

Cited by 2 publications

References 36 publications

Utility of hybrid PET/MRI multiparametric imaging in navigating SEEG placement in refractory epilepsy

Utility of hybrid PET/MRI multiparametric imaging in navigating SEEG placement in refractory epilepsy

Brain Magnetic Resonance Imaging Findings in Infantile Spasms

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