Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis

Pasha, Yadollah Zahed; Alizadeh-Tabari, Shaghayegh; Pasha, Ermia Zahed; Zamani, Mohammad

doi:10.1007/s12519-020-00339-3

Cited by 23 publications

(8 citation statements)

References 36 publications

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“…(2) MDT nursing training: the training included the attention items of jaundice nursing, symptomatic nursing measures for related complications, the use of the Newborn Early Warning Score (NEWS) scale, concepts and methods of MDT nursing, communication with parents, and intervention techniques. The work plan of the MDT was clarified, the team meetings were held regularly, the effect evaluation and revision plan of treatment and nursing programs were timely conducted, problems were identified, and measures were improved [ 14 – 16 ]. (3) Routine nursing was strengthened based on the MDT concept.…”

Section: Methodsmentioning

confidence: 99%

Effect of Systematic Holistic Nursing Combined with the MDT Teaching Method in the Nursing of Neonatal Jaundice and Its Impact on the Recovery of the Newborns’ Physiological Function

Dai

Yin

et al. 2021

Journal of Healthcare Engineering

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The application effect of systematic holistic nursing combined with the multidisciplinary team (MDT) in the nursing of neonatal jaundice was explored. This study was a retrospective control study. 90 cases of neonatal jaundice admitted to our hospital (February 2020–February 2021) were equally split into group P treated with routine nursing and group Q treated with systematic holistic nursing combined with MDT. The application effect of the two nursing programs was compared and analyzed. Groups P and Q showed no statistical difference in general data ( P > 0.05 ). Compared with group P, the jaundice regression time, hospitalization time, time of first defecation, and time of meconium turning yellow of group Q were notably shorter, and the body weight and total treatment efficiency of group Q were notably higher ( P < 0.05 ). From the third day, the daily jaundice indexes between the two groups were different; that is, the indexes of group Q were notably lower compared with group P ( P < 0.05 ). The scores of environmental nursing, special nursing, basic nursing, and service attitude in group Q were notably higher compared with group P ( P < 0.05 ). In the nursing process of neonatal jaundice, the combination of systematic holistic nursing and MDT can effectively shorten the time of first defecation and meconium turning yellow, reduce jaundice indexes, promote the recovery of the physiological function, and improve the clinical efficacy and nursing quality.

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Section: Methodsmentioning

confidence: 99%

Effect of Systematic Holistic Nursing Combined with the MDT Teaching Method in the Nursing of Neonatal Jaundice and Its Impact on the Recovery of the Newborns’ Physiological Function

Dai

Yin

et al. 2021

Journal of Healthcare Engineering

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“…Thyroid hormones revealed that the TSH of baby was 13.334mIU/L, which increased to 16mIU/L over two weeks of oral administration of euthyroxine. An epidemiological survey in Iran conducted that hypothyroidism is responsible for around 4.2% of hyperbilirubinemia [ 7 ]. Although the large portion of CH manifestations are protracted jaundice, several large-sample studies have shown that congenital hypothyroidism can produce severe hyperbilirubinemia, prompting transfusion exchange [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Severe neonatal hyperbilirubinemia secondary to combined RhC hemolytic disease, congenital hypothyroidism and large adrenal hematoma: a case report

et al. 2022

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Background ABO blood group incompatibility, neonatal sepsis, G-6-PD deficiency, thyroid dysfunction, and hereditary spherocytosis are all probable causes of neonatal hyperbilirubinemia. However, the etiology of some hyperbilirubinemia is extremely complicated, which may be caused by multiple factors, resulting in severe jaundice. We report a case of severe jaundice due to three causes, showing the significance for the investigation of the etiology of neonatal hyperbilirubinemia. Case presentation At 96 h of life, a full-term and vaginal delivery male infant with yellowish discoloration of body was transferred to our hospital. When he entered neonatal intensive care unit on the fourth day after birth, he developed jaundice and the transcutaneous bilirubin was 28 mg/dl. Total bilirubin was 540.2 μmol/L, while the indirect bilirubin was 516.7 μmol/L. Both parents and the baby’s blood types were O Rh(D +), and direct coomb’s test was negative. But mother’s indirect coomb’s test was positive. Investigating for minor blood group revealed that the father’s blood type of Rh was CCDee, the mather’s was ccDEE, and CcDEe for the baby. After intensive phototherapy and double volume exchange transfusion, the total bilirubin remained at 303 μmol/L. At day 10, the bilirubin level was 303.5 μmol/L, intensive phototherapy was continued, and intravenous immunoglobulin was used again. The test for thyroid hormones at day 10, the TSH was 13.334mIU/L. And the screening for congenital hypothyroidism showed the TSH was 33mIU/L. Because of the palpable abdominal mass, ultrasound and MRI was done, showed a huge mass in the right adrenal gland. Brainstem auditory evoked potential was performed at day 7, which indicated hearing impairment (65db for left ear and 70db for the right). Euthyrox and intermittent phototherapy were given as following treatment. The jaundice did not subside until the 12th day. Conclusion Even if their parents' ABO blood group and Rh (d) are consistent, a Coomb test is required for newborns with hyperbilirubinemia since they may have minor blood group incompatibilities. When bilirubin rises rapidly or the clinical treatment effect is inadequate, additional causes should be aggressively screened. Adrenal ultrasound should be performed on newborns with palpable abdominal mass, anemia and jaundice to determine whether there is adrenal hemorrhage.

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“…Exchange transfusion is an effective treatment for neonates with severe hyperbilirubinemia [ 18 , 19 ]. Exchange transfusion that could promptly reduce bilirubin levels involves removal of the newborn’s blood with high levels of circulating bilirubin and simultaneous replacement with compatible donor blood.…”

Section: Discussionmentioning

confidence: 99%

Intravenous immunoglobulin G in the treatment of ABO hemolytic disease of the newborn during the early neonatal period at a tertiary academic hospital: a retrospective study

et al. 2021

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Objective To evaluate the efficacy and safety of intravenous immunoglobulin G (IVIG) in infants with ABO hemolytic disease of the newborn (HDN). Methods Infants with moderate-to-severe ABO HDN during early neonatal period (<7 days) at our hospital in 2017 were included in this retrospective study. Patients treated with IVIG and phototherapy were classified as the IVIG group, and those who only received phototherapy were classified as the phototherapy only group. Results Forty-six patients were classified into the IVIG group and 68 other patients were classified into the phototherapy only group. There was no significant difference in duration of phototherapy, hospitalization periods, needs for exchange transfusion, transfusions, and incidence of bilirubin-induced neurological sequelae between these two groups (P = 0.20, 0.27, 0.65, 0.47, 0.78, respectively). Conclusion It seems unnecessary to expose neonates to IVIG in moderate-to-severe ABO HDN when the available data show no appreciable benefits.

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Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis

Cited by 23 publications

References 36 publications

Effect of Systematic Holistic Nursing Combined with the MDT Teaching Method in the Nursing of Neonatal Jaundice and Its Impact on the Recovery of the Newborns’ Physiological Function

Effect of Systematic Holistic Nursing Combined with the MDT Teaching Method in the Nursing of Neonatal Jaundice and Its Impact on the Recovery of the Newborns’ Physiological Function

Severe neonatal hyperbilirubinemia secondary to combined RhC hemolytic disease, congenital hypothyroidism and large adrenal hematoma: a case report

Intravenous immunoglobulin G in the treatment of ABO hemolytic disease of the newborn during the early neonatal period at a tertiary academic hospital: a retrospective study

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