Etoricoxib improves pain, function and quality of life: results of a real‐world effectiveness trial

Abstract

In OA patients experiencing inadequate relief from a wide variety of analgesics, pain, function, quality of life, and treatment satisfaction significantly improved when switched to etoricoxib.

Expect analgesic failure; pursue analgesic success

“…The problem is the dearth of data to help devise starting, stopping, and switching rules. Currently, we have no good evidence from clinical trials that switching is successful in pain; we have a single study of limited methodological quality 17 and a suggestion of differences between closely related tricyclics. 18 Switching drugs works in other conditions, like depression, where randomised trials show that while drugs used individually benefited fewer than half of patients, the majority benefited when failure was followed by another drug.…”

Cardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysis

“…Because of the small number of RCTs, it was not possible to divide the CV and GI events according to site and severity of occurrence. One observational study and one single arm study were included, but these studies did not describe the safety outcome of interest and so were not included [35,36]. Second, meta-analysis was performed only with studies of short duration.…”

Chronic Back Pain: From Pathogenetic Concepts to Therapeutic Strategies

“…Эти находки позволяют рассматривать эторикоксиб как целевой противовоспалительный пре-парат, воздействующий на периферические и, с высокой долей вероятности, на центральные механизмы хрониче-ской боли. Наличие комплексного двойного механизма действия у эторикоксиба, возможно, объясняет более высокую эффективность этого препарата даже в тех слу-чаях, когда другие НПВП при длительном приеме оказы-ваются недостаточно эффективными [25].…”