ETS-GS, a New Antioxidant, Ameliorates Renal Ischemia-Reperfusion Injury in a Rodent Model

Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation

“…Equivalent degree of the renal ischemia has been fashioned by other pollsters. 48 After fourth week of RIR in nephrectomized rats exhibited noteworthy escalate in SBP, DBP, MABP, EDP, dp/dt max , and dp/dt min which are in synchronization with findings of previous researcher, 49 who has reported hypertension as foremost concern for expansion of acute renal diseases. In the present delve, berberine treatment illustrated considerable diminish in SBP, DBP, MABP, EDP, dp/dt max , and dp/dt min .…”

Vitamin E Derivative ETS-GS Reduces Liver Ischemia-Reperfusion Injury in Rats

“…Our findings suggest that ETS-GS ameliorates liver I/R injury by inhibiting cytokine secretion. Moreover, results from our previous studies suggest that ETS-GS strongly inhibits serum cytokine secretion after LPSinduced systemic inflammation [5], and produces a strong anti-oxidative effect, thereby protecting against renal cellar damage after I/R injury [6]. Taken together, our findings indicate that ETS-GS shows potential for use as a new therapeutic tool against various I/R injuries.…”

“…Similarly, the vitamin E derivative ETS-GS (provided by Oga Research Co., Osaka, Japan), which is synthesized from vitamin E, taurine, and glutathione, produced strong antioxidative and anti-inflammatory actions against various organ injuries and systemic inflammation [5,6]. In the present study, we evaluated the ability of ETS-GS to inhibit cytokine secretion and prevent liver I/R injury in rats.…”

The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury

“…Antioxidants and anti-apoptotic therapy have been shown to be protective against I/R-mediated oxidative damage in different experimental models [8][9][10][11] . Protein kinase 2 (CK2) is a highly conserved and ubiquitously expressed serine/threonine kinase; it is a tetramer composed of two catalytic subunits (α and α ′ ) and two regulatory subunits (β ) in an α 2 β 2 , α α ′ β 2 , or α ′ 2 β 2 configuration 12 .…”