Étude De La Complexation Du Cadmium Et Du Zinc Avec l'ALENDRONATE (Acide 4-Amino-1-Hydroxybutylidène-1′1-Bisphosphonique)

Bone Tissue Disorders: Healing Through Coordination Chemistry

“…Another series of five coordination compounds containing alendronate and calcium, magnesium or zinc, was prepared: [21] Ca [18,19,42,43,46] Additional studies were carriedo ut on Caalendronate to determinet he effect of the particle size on the results of the cellular studies ( Figure 5). [21] This compound was prepared with particle sizes ranging from ca.…”

“…While the structure of some of these compounds was previously reported, no assessment of their biological activity was properly achieved. [42][43][44][45] Preliminary studies were insteadp erformed regarding the safety/cytotoxicity of some materials using NIH3T3 mousee mbryonicf ibroblast cell lines, which were exposed to 1, 10 or 100 mm concentration, for 1o r 3days. The compounds, and the corresponding free bisphosphonate drugs, presented as imilarb ehavior.A ll metal coordination systemsw ere well tolerated,w ith no significant changes in cell viability when administered at the lowest dose (1 mm), with the highest doses having an egative impacto n cell viability.…”

catena-Poly[diaquacadmium(II)-μ-(diethyl dichloromethylenebisphosphonato)-κ3O,O′:O′′-tetraaquacadmium(II)-μ-(diethyl dichloromethylenebisphosphonato)-κ3O:O′,O′′]

“…(Clearfield, 1998;Zhang & Clearfield, 1997;Alberti et al, 1996;Snover et al, 1996). To study the solid materials, several metal complexes of methylenebisphosphonate, [H 2 C(PO 3 H) 2 ] 2À , and its analogues etidronate, [(CH 3 )(HO)C(PO 3 H) 2 ] 2À , and alendronate, [(NH 3 CH 2 -CH 2 CH 2 )(HO)C(PO 3 H) 2 ] 2À , including some Cd complexes, have been prepared and characterized (Serre & Fé rey, 2002;Barthelet et al, 2000;Sergienko et al, 1998;El Messbahi et al, 2000;Dufau et al, 1995).…”

Racemic trans-1,2-diaminocyclohexane as a template in the synthesis of ligands for transition metal and actinide in vivo detoxification

“…Phosphonic derivatives, and the more elaborated hydroxy bis phosphonic acids are widely used as complexing agents for calcium, zinc 2,3 and/or a number of bivalent metals, they are involved in a large number of biochemical processes and diseases treatments 4,5 or diagnostics (scintigraphy in the case of 99m Tc). The aim of this report is to build polyphosphonic compounds grafted to a poly amino tetra-substituted template and to analyze their properties including acidity, stability, kidney clearance, all associated with a mandatory low level toxicity.…”