“Eucalyptol: An Alternative Green Solvent for the Michael Addition of Indoles to α, β‐Unsaturated Ketones and Nitrostyrenes”

Abstract

Reduction of carbon footprint generated by organic solvents via replacing them with greener solvents is of great interest in recent times. Herein, we report a Michael addition reaction of indoles to α, β-unsaturated ketones, and nitrostyrene using reusable and low toxic eucalyptol as a green solvent, and Fe(OTs) 3 ⋅ 6H 2 O as green catalyst. This methodology offers broad substrate scope and excellent yields (up to 90 %) in short reaction times.