Eudragit, a Nifty Polymer for Anticancer Preparations: A Patent Review

Kriplani, Priyanka; Guarve, Kumar

doi:10.2174/1574892816666211013113841

Cited by 10 publications

(2 citation statements)

References 41 publications

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“…Eudragit, a biocompatible polymer derived from polymethacrylate, is frequently utilized in the preparation of nanosuspensions to stabilize their structure, leading to prolonged drug release times and heightened efficacy. This highlights the beneficial impact of altered surface proprieties on nanosuspensions to improve bioavailability and drug release times [ 79 ].…”

Section: Nano-based Drug Delivery Systems In Dry Eye Diseasementioning

confidence: 99%

Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease

Coco,

Buffon,

Taloni

et al. 2024

Nanomaterials

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Dry eye disease (DED) incidence is continuously growing, positioning it to become an emergent health issue over the next few years. Several topical treatments are commonly used to treat DED; however, reports indicate that only a minor proportion of drug bioavailability is achieved by the majority of eye drops available on the market. In this context, enhancing drug ability to overcome ocular barriers and prolonging its residence time on the ocular surface represent a new challenge in the field of ocular carrier systems. Therefore, research has focused on the development of multi-functional nanosystems, such as nanoemulsions, liposomes, dendrimers, hydrogels, and other nanosized carriers. These systems are designed to improve topical drug bioavailability and efficacy and, at the same time, require fewer daily administrations, with potentially reduced side effects. This review summarizes the different nanotechnologies developed, their role in DED, and the nanotechnology-based eyedrops currently approved for DED treatment.

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Section: Nano-based Drug Delivery Systems In Dry Eye Diseasementioning

confidence: 99%

Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease

Coco,

Buffon,

Taloni

et al. 2024

Nanomaterials

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“…Eudragit ® is a polymer that has demonstrated its potential as a coating material and matrix former in various drug delivery systems to control drug release. By enabling sitespecific drug delivery, it can enhance the bioavailability of drugs and reduce associated side-effects or toxicity, particularly for anticancer drugs [7]. Eudragit ® is a versatile range of polymers composed of methacrylic acid and methyl methacrylate, representing anionic copolymers commonly used to stabilize and improve the bioavailability of various substances.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Polymer and Solvent Variables on the Nanoencapsulation of the Flavonoid Quercetin: Preliminary Study Based on Eudragit® Polymers

et al. 2023

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Eudragit® polymers have proven their potential as a means to control the release of aqueous insoluble drugs in various delivery systems as polymer nanoparticles (PNPs). The size (S) and polydispersity index (PDI) of PNPs are crucial factors for their interaction with biological systems from a pharmaceutical standpoint. This study aimed to determine the impact of the volumes of the organic phase (OP) and aqueous phase (AP), as well as the polymer amount (PA), on the size and PDI of PNPs prepared using the nanoprecipitation method for encapsulating quercetin (Qr). The study also evaluated the toxic effects of PNPs on human erythrocytes. The PNPs were prepared using preformed polymers derived from methacrylic acid and polyvinyl alcohol (PVA) as a surfactant. The nanoprecipitation technique enabled the production of particles smaller than 200 nm with a PDI lower than 0.2, and the study established the significant impact (p < 0.05) of the three variables related to the polymers and solvents. The selected PNPs contained 5 mg of Qr and 50 mg of Eudragit polymers (1:10 w/w Eudragit® EPO, E100, L100, and Eudragit L100-55) and diverse concentrations of PVA. The study found that including PVA in the AP increased the Qr encapsulation by up to 98%. The hemolytic potential of Eudragit® PNPs and Qr was assessed in human erythrocytes, with no significant cytotoxic activity observed (p < 0.001) compared with the control. In conclusion, via the nanoprecipitation technique, preparing PNPs with defined and homogeneous S to entrap the flavonol Qr efficiently is possible.

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Smart Polymer‐Based Delivery Systems for Curcumin in Colon Cancer Therapy: A Review

Kamath,

Donadkar,

Nair

et al. 2024

Phytotherapy Research

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Curcumin, a well‐known bioactive component, has profound effects against colon cancer. However, the limitations are poor systemic absorption, off‐target distribution, chemical instability, short half‐life, and less concentration reaching tumor tissues. Several drug delivery systems have been evaluated so far to deliver effective concentrations of curcumin to the malignant tissues. This review aims to explore the role of smart polymers in overcoming limitations in curcumin delivery against colon cancer. Literature of the past 10 years was collected from Scopus, PubMed/Medline, Google Scholar, and Science Direct using specific keywords. Several preclinical and clinical studies of curcumin against colon cancer with the inclusion of smart polymers were screened using keywords like “FDA‐approved biomaterials,” “stimuli‐responsive polymer,” “smart biomaterial,” and so forth. Smart polymer phrase is used to describe all the mentioned polymers in the manuscript. Stimuli‐responsive polymers, including poly‐lactic‐co‐glycolic acid (PLGA), polyethylene glycol (PEG), Eudragit, cyclodextrin, and chitosan, have emerged as promising candidates for curcumin delivery against colon cancer. These polymers facilitate controlled drug release in response to stimuli such as temperature, pH, and enzymes, while offering biocompatibility, biodegradability, and safety. The five selected FDA‐approved smart polymers exhibit the potential for enhancing curcumin delivery against colon cancer.

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Eudragit, a Nifty Polymer for Anticancer Preparations: A Patent Review

Cited by 10 publications

References 41 publications

Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease

Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease

Influence of the Polymer and Solvent Variables on the Nanoencapsulation of the Flavonoid Quercetin: Preliminary Study Based on Eudragit® Polymers

Smart Polymer‐Based Delivery Systems for Curcumin in Colon Cancer Therapy: A Review

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