Eukaryote DNA Replication and Recombination: an Intimate Association

McFarlane, Ramsay J.; Al-Zeer, Khalid; Dalgaard, Jacob Z.

doi:10.5772/19995

DNA Replication-Current Advances 2011

DOI: 10.5772/19995

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Eukaryote DNA Replication and Recombination: an Intimate Association

Ramsay J. McFarlane¹,

Khalid Al-Zeer²,

Jacob Z. Dalgaard³

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2012

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The immortal strand hypothesis: still non-randomly segregating opinions

Wakeman

Hmadcha

Soria

et al. 2012

BioMolecular Concepts

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Cairns first suggested a mechanism for protecting the genomes of stem cells (SCs) from replicative errors some 40 years ago when he proposed the immortal strand hypothesis, which argued for the inheritance of a so-called immortal strand by an SC following asymmetric SC divisions. To date, the existence of immortal strands remains contentious with published evidence arguing in favour of and against the retention of an immortal strand by asymmetrically dividing SCs. The conflicting evidence is derived from a diverse array of studies on adult SC types and is predominantly based on following the fate of labelled DNA strands during asymmetric cell division events. Here, we review current data, highlighting limitations of such labelling techniques, and suggest how interpretation of such data may be improved in the future.

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The immortal strand hypothesis: still non-randomly segregating opinions

Wakeman

Hmadcha

Soria

et al. 2012

BioMolecular Concepts

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Eukaryote DNA Replication and Recombination: an Intimate Association

Cited by 1 publication

References 266 publications

The immortal strand hypothesis: still non-randomly segregating opinions

The immortal strand hypothesis: still non-randomly segregating opinions

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