European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis

Stange, Eduard F.; Travis, Simon; Vermeire, Séverine; Reinisch, Walter; Geboes, Karel; Barakauskienė, Aušrinė; Feakins, Roger; Fléjou, Jean‐François; Herfarth, Hans H; Hommes, Daniël W.; Kupčinskas, Limas; Lakatos, László; Mantzaris, Gerassimos J.; Schreiber, Stefan; Villanacci, Vincenzo; Warren, Bryan F.

doi:10.1016/j.crohns.2007.11.001

Cited by 505 publications

(418 citation statements)

References 190 publications

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“…Steroid therapy may have completely stopped if it had been restarted within the last 90 days. 13 At inclusion, the daily dose of steroids had to range between 10 and 40 mg prednisone or equivalent. Patients could have active or inactive disease at inclusion, as defined by a Mayo Clinic score (range, 0-12, with higher scores indicating more active disease) of >2 or ≤2.…”

Section: Patientsmentioning

confidence: 99%

Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis

et al. 2016

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Section: Patientsmentioning

confidence: 99%

Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis

et al. 2016

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“…Steroid-dependent patients were either unable to reduce steroids to below 10 mg/ day of prednisolone (or equivalent) within 3 months of starting them without recurrent active disease, or relapsed within 3 months of stopping steroids. Steroid-resistant patients had active disease despite prednisolone doses of up to 0.75 mg/kg/ day over a 4-week period (11).…”

Section: Steroid Dependency and Resistance To Steroidmentioning

confidence: 99%

“…The ECCO definitions of steroid-dependent and steroid-resistant patients (2008) were used (11). Steroid-dependent patients were either unable to reduce steroids to below 10 mg/ day of prednisolone (or equivalent) within 3 months of starting them without recurrent active disease, or relapsed within 3 months of stopping steroids.…”

Section: Steroid Dependency and Resistance To Steroidmentioning

confidence: 99%

Clinical course and predictors of total colectomy in ulcerative colitis; a referral center experience from Turkey

Kalkan

Dağlı²,

Kekilli³

et al. 2015

Turk J Gastroenterol

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Background/Aims: We aimed to describe the clinical course of Ulcerative colitis (UC) and the factors that predict the need for total colectomy in Turkish patients with severe UC receiving regular follow up. Materials and Methods: We analyzed the demographic and clinical characteristics of 612 patients with UC receiving regular follow up between 1994 and 2010 in a tertiary referral center in Ankara. Results: Men accounted for 58% of patients (M:F ratio, 1.4:1), and the mean age at diagnosis was 37.9 years. Of these, 32% had distal colitis and 8.8% had further extension, and 39 patients (6.4%) had chronic active disease. Steroid dependency and steroid resistance rates were 7.5% and 17.2%, respectively. In multivariate analysis, steroid dependency (p=0.04), steroid resistance (p=0.002), further extension (p<0.001), presence of extensive disease (p=0.006), and chronic active disease (p<0.001) were independent predictors of the need for total colectomy. Patients with chronic active disease had lower total colectomy free survival (p<0.001). Conclusion: The predictors of total colectomy were comparable with those previously reported in the literature. However, we identified further extension in disease localization to predict the need for total colectomy.

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“…[68] Analysis of multiple biopsies yields a positive diagnosis of Crohn's disease in 64% of the cases compared to 24% for one single rectal biopsy. [64,69] Biopsies of the terminal ileum are mainly useful in patients with inflammatory diarrhoea. [70,71] The differential diagnosis between infections and IBD relies on the distribution of the inflammatory infiltrate in the lamina propria and the presence of architectural changes.…”

Section: Inflammatory Conditionsmentioning

confidence: 99%

Endoscopy and Histopathology

Geboes¹,

Geboes²,

Jouret‐Mourin³

2013

Endoscopy

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European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis

Cited by 505 publications

References 190 publications

Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis

Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis

Clinical course and predictors of total colectomy in ulcerative colitis; a referral center experience from Turkey

Endoscopy and Histopathology

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