Eutectic-based liposome as a potential delivery system of paeonol

Abstract

A THEDES based on paeonol and lauric acid was constructed and showed potential applicability for the delivery of paeonol.

Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery

“…The preparation of eutectic-based liposome of paeonol and lauric acid in a molar ratio of 1:1 was reported, and the developed THEDES exhibited enhanced water solubility in comparison to the pure APIs. The obtained liposomes were 120 nm in size, with an encapsulation efficiency of 84 %, proving to be a better strategy for delivering natural bioactives [ 90 ]. Similarly, carnosol, rosmarinic acid, carmosic acid, and caffeic acid were extracted from rosemary by the utilization of NADES using heat, stirring, and ultrasound-assisted extraction techniques.…”