Eutectic solvents with tuneable hydrophobicity: lipid dissolution and recovery

Lo, Calvin; Semerel, Jeltzlin; Berg, C. van den; Wijffels, René H.; Eppink, M.H.M.

doi:10.1039/d1ra00306b

Cited by 12 publications

(2 citation statements)

References 39 publications

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“…It is not clear why C extracted more phospholipids, but it is possible that intermolecular interactions between polar groups in the TV NADES reduced the availability of these groups to disrupt phospholipid‐phospholipid and phospholipid‐protein interactions in the sample matrix (Magee & Parmryd, 2003). It is also possible that interactions between TV NADES components increased the hydrophobicity of these media, making them less amenable to dissolution of more polar components (Lo et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Hydrophobic natural deep eutectic solvents for marine lipid extraction

Topal,

Card,

Mackenzie

et al. 2023

J Americ Oil Chem Soc

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Abstract‘Type V' natural deep eutectic solvents (TV NADES) are a novel class of solvent media with many potential ‘green chemistry’ applications. Here, we assess the potential of two TV NADES: menthol:carvacrol (M:C) and menthol:thymol (M:T), and a single terpenoid extraction media carvacrol (C), as media from total lipid extraction of three compositionally diverse, freeze‐dried marine tissues: hoki (Macruronus novaezelandaiae), jack mackerel (Trachurus declivis) and green‐lipped mussel (kuku, Perna canaliculus). Room temperature extraction yields into these media were benchmarked relative to lipid yields from chloroform‐methanol‐water extractions. Relative extraction yields using the M:C and M:T media were (both) 87% for jack mackerel, 85%–87% for hoki, and 43%–47% for green‐lipped mussels. Comprehensive chemical analyses of TV NADES lipid extracts suggested that neutral lipids were extracted in greater yield than phospholipids, and that phosphatidylinositol, lysophospholipids and (in the case of mussels) ceramideaminoethylphosphonates were particularly resistant to extraction into C, M:C and M:T. C—a thymol isomer that, unlike menthol and thymol is a liquid at room temperature—appeared to perform (marginally) better than M:C and M:T systems, implying there may be no advantage to using the TV NADES over a single terpenoid with similar chemistry for total lipid extraction.

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Section: Resultsmentioning

confidence: 99%

Hydrophobic natural deep eutectic solvents for marine lipid extraction

Topal,

Card,

Mackenzie

et al. 2023

J Americ Oil Chem Soc

View full text Add to dashboard Cite

show abstract

“…34 Moreover, a recovery of ∼42% has been reported for curcuminoids from a choline chloride-based DES turmeric extract employing an anti-solvent precipitation technique (Patil et al , 2021). 100 A 75% recovery of sunflower oil and algae oil has been achieved by Lo et al 101 by shifting the hydrophobicity spectrum of a semi-hydrophobic solvent consisting of the hydrophilic imidazole and the hydrophobic hexanoic acid. Polarity switch of a hydrophobic DES synthesized from N , N -dimethylcyclohexylamine and n -butanol in order to recover (91%) β-carotene from millets has also been reported.…”

Section: Recovery Of Bioactive Compounds From Des Extracts and Des Re...mentioning

confidence: 99%