Evading the Toll booth: How “silent” flagellins may bind yet fail to activate TLR5

Abstract

The nature of flagellin–Toll-like receptor 5 (TLR5) interactions, depending on binding to and activation of TLR5, may hold a key to the distinct differences in gut microbiome and intestinal immune function in different populations around the world (see related Research Article by Clasen et al .).