Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid Arthritis
Clifton O. Bingham,
Emily Molina,
Amy Praestgaard
et al.
Abstract:ObjectiveThe aim of this study was to evaluate changes in fatigue measured by Patient‐Reported Outcome Measurement Information System (PROMIS)‐Fatigue scores in patients with rheumatoid arthritis (RA) who received sarilumab and to assess the proportion of patients achieving clinically meaningful change.MethodsData from three phase 3 randomized controlled trials of patients with RA who received sarilumab—MOBILITY, TARGET, and MONARCH—were evaluated. The 10 RA‐relevant items from the 13‐item Functional Assessmen… Show more
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