Evaluating Relationships between Visceral Fat Measures and Adipokines Concentrations among Women with a History of Preeclampsia

Chandrasekaran, Suchitra; Barry, Darcy; Melhorn, Susan J.; Easterling, Thomas R.; Gammill, Hilary S.; Schur, Ellen A.

doi:10.1055/s-0039-1692454

“…Conversely, one case-control study with 117 pregnant women found no significant difference in maternal serum resistin levels between PE patients and healthy controls; however, it reported a positive correlation between serum resistin and subcutaneous fat area in PE women [32]. A secondary analysis of 64 patients who had a history of PE and healthy controls 10 years after delivery found maternal resistin concentrations to be similar among both groups [33].…”

Section: Resistin In Gdm and Pementioning

confidence: 96%

Adipokines in Pregnancy: A Systematic Review of Clinical Data

Kabbani

¹

,

Blüher

²

,

Stepan

³

et al. 2023

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Adipokines are signaling proteins involved in metabolic, endocrinological, vascular and immunogenic processes. Associations of various adipokines with not only insulin resistance but also with increased insulin sensitivity, increased systolic blood pressure, and atherosclerosis highlight the significance of adipokines in several components of metabolic syndrome and metabolic diseases in general. As pregnancy presents a unique metabolic state, the role of adipokines in pregnancy, and even in various pregnancy complications, appears to be key to elucidating these metabolic processes. Many studies in recent years have attempted to clarify the role of adipokines in pregnancy and gestational pathologies. In this review, we aim to investigate the changes in maternal adipokine levels in physiological gestation, as well as the association of adipokines with pregnancy pathologies, such as gestational diabetes mellitus (GDM) and preeclampsia (PE). Furthermore, we will analyze the association of adipokines in both maternal serum and cord blood with parameters of intrauterine growth and various pregnancy outcomes.

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“…Triplane tissue Doppler imaging (TDI) has fast imaging speed and high image resolution and overcomes the interference of respiratory motion [ 9 ]. Nowadays, triplane TDI has been widely used in the diagnosis of congenital heart diseases, pulmonary embolism, pulmonary hypertension, and other diseases [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Two-Dimensional Ultrasound and Triplane Tissue Doppler Ultrasound of Patients with Severe Preeclampsia

Tong

¹

,

Tian

²

2022

Computational and Mathematical Methods in Medicine

0

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This study was to investigate the cardiac function characteristics under two-dimensional ultrasound and triplane tissue Doppler imaging (TDI) of patients with severe preeclampsia (SPE). 28 SPE patients with singleton pregnancy from January 2018 to December 2020 were included in the SPE group. 25 healthy nonpregnant women of reproductive age were taken as the control group (Ctrl group), and 26 normal pregnant women with singleton pregnancy were selected as the normal group (Norm group); all the research objects underwent ultrasonography. The morphological and functional indexes of left and right ventricles were compared among the cases in different groups. The results showed that the left ventricular end-diastolic period diameter (LVEDd), left ventricular relative wall thickness (LV-RWT), left ventricular mass index (LVMi), left anterior descending (LAd), left ventricular E / e and e / a values, right ventricular diameter (RV-D), right ventricular anterior wall thickness (RVAW), a value, right atrial septum (RA-S), pulmonary artery systolic pressure (PASP), left ventricular end-systolic period diameter (LVEds), interventricular septal thickness (IVSd), posterior wall thickness (PWd), end-diastolic period volume (EVD), end-systolic period volume (ESV), relative wall thickness (RWT), sphericity index (SpI), left atrium volume index (LAVi), and E / e value of patients in the SPE group were higher than those in the Ctrl group and the Norm group ( P < 0.05 ). The mitral annular plane systolic excursion (MAPSE), s value, tricuspid annual plane systolic excursion (TAPSE), ratio of early diastolic blood flow velocity to late diastolic blood flow velocity ( E / A ), ratio of peak early diastolic velocity to peak late diastolic velocity ( e / a ), peak early diastolic velocity ( e ), and ejection fraction (EF) of the SPE group were lower than those of the Ctrl group and the Norm group ( P < 0.05 ). The ratio of mitral valve early diastolic blood flow velocity to peak early diastolic velocity ( E / e ) of the Norm group was higher than that of the Ctrl group ( P < 0.05 ). In two-dimensional ultrasound of the SPE group, the maximum difference in time from the start to the peak of systole (Ts) of the right ventricle between the basal and middle segments of the lateral wall and that of interventricular septum (RV-Ts-max) was 31.56 ± 0.39 % . The maximum difference in time to peak of early diastole (Te) under the same condition (RV-Te-max) was 47.16 ± 0.19 % . Left ventricular LV-Ts-max and LV-Te-max were 9.83 ± 0.80 % and 8.37 ± 0.68 % , respectively, in triplane TDI, which were considerably higher than those in the Ctrl and Norm groups ( P < 0.05 ). It suggested that two-dimensional ultrasound and triplane TDI could reflect the ventricular morphology as well as diastolic and systolic function injury in patients, which offered a reference basis for the diagnosis of SPE.

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Maternal adiposity measures and hypertensive disorders of pregnancy: a meta-analysis

Xiang,

Sui,

Ding

et al. 2024

BMC Pregnancy Childbirth

1

0

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Background Hypertensive disorders of pregnancy (HDP) are a prevalent complication during pregnancy with significant implications for maternal and perinatal health globally. Maternal obesity is a known risk factor for HDP. This review sought to identify adiposity indicators in early pregnancy that are linked to the development of HDP. Methods We conducted a systematic search of the PubMed, Science Citation Index (Web of Science), and Embase databases. Screening and quality evaluation of studies was conducted independently by two reviewers. Both random effects meta-analysis and narrative synthesis were performed. Results Thirty-one studies were included with a pooled sample of 81,311 women. The meta-analysis showed that the odds of HDP were significantly increased by higher pregnancy measures of adiposity (pre-pregnancy body mass index (OR = 2.14, 95%CI: 1.67–2.75), visceral adipose tissue (OR = 1.79, 95%CI: 1.01–3.16), subcutaneous adiposity thickness (OR = 1.67, 95%CI: 1.36–2.05), waist circumference (OR = 2.20, 95%CI: 1.37–3.54), waist to-hip ratio (OR = 3.08, 95% CI: 1.38–6.87), weight gain (OR = 1.69, 95%CI: 1.42–2.02) and percentage body fat (OR = 1.71, 95%CI: 1.16–2.53)). Epicardial fat thickness was significantly associated with HDP, although limited data were available. Conclusions The results of our study highlight the importance of investigating the predictive value of adiposity measures in identifying the risk of HDP to tailor care towards women at the highest risk. Supplementary Information The online version contains supplementary material available at 10.1186/s12884-024-06788-2.

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Evaluating Relationships between Visceral Fat Measures and Adipokines Concentrations among Women with a History of Preeclampsia

Cited by 4 publications

References 31 publications

Adipokines in Pregnancy: A Systematic Review of Clinical Data

Adipokines in Pregnancy: A Systematic Review of Clinical Data

Two-Dimensional Ultrasound and Triplane Tissue Doppler Ultrasound of Patients with Severe Preeclampsia

Maternal adiposity measures and hypertensive disorders of pregnancy: a meta-analysis

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