Evaluating the Affective Component of the Cerebellar Cognitive Affective Syndrome

Wolf, Uri; Rapoport, F.R.C.P.C. Mark J.; Schweizer, Tom A.

doi:10.1176/jnp.2009.21.3.245

Cited by 152 publications

(59 citation statements)

References 46 publications

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“…42 Therefore, a global proteomics analysis on the control and irradiated cerebellum and on cerebellar synaptosomes was performed. This showed similar alterations to signalling pathways as the hippocampus and cortex.…”

Section: Long-term Molecular Consequences Of Ionising Radiation In Cementioning

confidence: 99%

Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex

Kempf¹,

Sepe

Toerne³

et al. 2015

J. Proteome Res.

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Recent epidemiological data indicate that radiation doses as low as those used in computer tomography may result in long-term neurocognitive side effects. The aim of this study was to elucidate long-term molecular alterations related to memory formation in the brain after low and moderate doses of γ radiation. Female C57BL/6J mice were irradiated on postnatal day 10 with total body doses of 0.1, 0.5, or 2.0 Gy; the control group was sham-irradiated. The proteome analysis of hippocampus, cortex, and synaptosomes isolated from these brain regions indicated changes in ephrin-related, RhoGDI, and axonal guidance signaling. Immunoblotting and miRNA-quantification demonstrated an imbalance in the synapse morphology-related Rac1-Cofilin pathway and long-term potentiation-related cAMP response element-binding protein (CREB) signaling. Proteome profiling also showed impaired oxidative phosphorylation, especially in the synaptic mitochondria. This was accompanied by an early (4 weeks) reduction of mitochondrial respiration capacity in the hippocampus. Although the respiratory capacity was restored by 24 weeks, the number of deregulated mitochondrial complex proteins was increased at this time. All observed changes were significant at doses of 0.5 and 2.0 Gy but not at 0.1 Gy. This study strongly suggests that ionizing radiation at the neonatal state triggers persistent proteomic alterations associated with synaptic impairment.

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Section: Long-term Molecular Consequences Of Ionising Radiation In Cementioning

confidence: 99%

Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex

Kempf¹,

Sepe

Toerne³

et al. 2015

J. Proteome Res.

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show abstract

“…In humans, the cerebellum plays an important role in motor control, and it may also be involved in some cognitive functions such as attention and language as well as in regulating fear and pleasure responses 47 . Functional imaging studies have shown cerebellar activation in relation to language, attention, and mental imagery; correlation studies have shown interactions between the cerebellum and non-motor areas of the cerebral cortex; and a variety of non-motor symptoms have been recognized in people with damage that appears to be confined to the cerebellum 48, 49 .…”

Section: Discussionmentioning

confidence: 99%

Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study

Liu

Wang

Zhang

et al. 2017

Sci Rep

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Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naïve and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children.

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“…The cerebellum is a structure attached to the bottom of the cerebral hemispheres of the brain that plays an important role in motor and cognitive functions [1]. Its surface is covered with finely spaced parallel grooves, in striking contrast to the broad irregular convolutions of the cerebral cortex.…”

Section: Anatomy Of Cerebellummentioning

confidence: 99%

“…Hydro alcoholic extracts of pomegranate peels were shown to cause significantly reduced blood glucose level in healthy and diabetic rats [107,108]. (1,2) or (1,6) glucopyranosyl substituents [110]. Barley possesses several medicinal applications.…”

Section: Pomegranatementioning

confidence: 99%

Cholesterol overload impairing cerebellar function: The promise of natural products

El‐Sayyad

2015

Nutrition

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Evaluating the Affective Component of the Cerebellar Cognitive Affective Syndrome

Cited by 152 publications

References 46 publications

Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex

Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex

Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study

Cholesterol overload impairing cerebellar function: The promise of natural products

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