2009
DOI: 10.1093/abbs/gmp084
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Evaluating the antitumor activity of combined photochemotherapy mediated by a meso-substituted tetracationic porphyrin and adriamycin

Abstract: The combined anticancer modality comprising porphyrins as photodynamic sensitizers and anticancer drugs has been an interesting subject for many researchers. In this study, the photochemotherapeutic effect mediated by simultaneous photoactivation of tetracationic meso-tetrakis(N-methyl-4-pyridyl) porphine tetratosylate (TMPyP) and adriamycin (ADM) were explored using human hepatocellular carcinoma cell line (HePG2). The efficiency of TMPyP acting in concert with ADM in the dark and in the presence of photoirra… Show more

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Cited by 5 publications
(4 citation statements)
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“…TMPyP was investigated for antimicrobial PDT against various organisms using various experimental conditions in which concentration and incubation time of TMPyP could play a major role for dark toxicity. Thus, we concluded to cover the broad range of published concentrations (1-366 lM) (6,7,24,25,27,(29)(30)(31)(32)(33)(34)(35)(36)(43)(44)(45) using TMPyP concentrations in our study from 0 to 250 lM. Incubation time in the present experiments was 1 h because most of incubation times published in literature ranged from a few minutes up to a few hours (6,7,24,25,27,(29)(30)(31)(32)(33)(34)(35)(36)(43)(44)(45).…”
Section: Discussionmentioning
confidence: 67%
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“…TMPyP was investigated for antimicrobial PDT against various organisms using various experimental conditions in which concentration and incubation time of TMPyP could play a major role for dark toxicity. Thus, we concluded to cover the broad range of published concentrations (1-366 lM) (6,7,24,25,27,(29)(30)(31)(32)(33)(34)(35)(36)(43)(44)(45) using TMPyP concentrations in our study from 0 to 250 lM. Incubation time in the present experiments was 1 h because most of incubation times published in literature ranged from a few minutes up to a few hours (6,7,24,25,27,(29)(30)(31)(32)(33)(34)(35)(36)(43)(44)(45).…”
Section: Discussionmentioning
confidence: 67%
“…However, experiments using eukaryotic cells showed partly the presence of a high toxicity against these cells even in the absence of light. Kassab observed a dark toxicity toward HepG2 cells especially in the presence of a cytostatic drug in combination with TMPyP (29). Dark toxicity was also described for various prokaryotic organisms like Pseudomonas aerugionosa (30), E. coli (31), Bacillus cereus (32) and Staphylococcus aureus (33) by several authors.…”
Section: Introductionmentioning
confidence: 91%
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“…In particular, caspase-3 is an effector caspase enrolled in the apoptosis execution final stage [ 4 , 29 ]. Accordingly, caspase-3 activation is routinely estimated by medicinal chemists to evaluate the apoptosis as an indication [ 30 , 31 ]. Therefore, the caspase-3 levels were assessed in A549 and DLD-1 cells employing Western blotting, as presented in Figure 1 .…”
Section: Resultsmentioning
confidence: 99%