Evaluating the Effect of a Natural Formulation Based on Hordeum Vulgare on the Recovery of COVID-19 Patients: Application of Survival Analysis in a Clinical Trial

Abstract

Background: Coronavirus disease 2019 (COVID-19) has affected the lives of people all over the world. Although researchers are working to manage and minimize the impact of the current COVID-19 pandemic, no definitive treatment method has been identified so far. The present clinical trial aimed to evaluate the survival of two groups of patients with COVID-19. Methods: The statistical population of this prospective clinical trial included 70 patients hospitalized in the Mofatteh Hospital in Varamin, Iran, from 13 May to 10 July 2020. The intervention and control groups were compared using the Kaplan-Meier method and log-rank test. Results: Patients in the intervention group had a higher survival rate than the control group. Conclusion: Hordeum vulgare increased the survival of patients.

Comparative efficacy of acupuncture, venesection, and physical therapy on chronic low back pain outcomes, a randomized clinical trial

“…Previous studies showed the positive effect of venesection in the treatment of vertigo, dizziness, carpal tunnel syndrome, musculoskeletal disease, sciatica, and non-specific pains of the back, neck, and arms. The most commonly reported benefit of this technique is pain relief 12 , 23 – 25 . Amini et al 12 hypothesized that venesection would alleviate the pain, thus improving the quality of life in patients with sciatica.…”

“…The most commonly reported benefit of this technique is pain relief 12 , 23 – 25 . Amini et al 12 hypothesized that venesection would alleviate the pain, thus improving the quality of life in patients with sciatica.…”

“…Bloodletting techniques, such as cupping and venesection, have been used centuries to relieve musculoskeletal pain. While previous studies reported significant effectiveness of venesection in the treatment of different types of disease such as epistaxis, hepatitis, migraine, bronchitis, amenorrhoea, haemorrhoids, and musculoskeletal pains 12 , several clinical trials reported the role of venesection in pain relief, rehabilitation, and improvement of the quality of life of LBP patients 13 .…”

The efficacy of herbal medicines on the length of stay and negative conversion time/rate outcomes in patients with COVID-19: a systematic review

“…Antiviral activity is also shown by Artemisia annua which is one of the ingredients of Reduning Injection. Artemisia annua can inhibit SARS-CoV-2 attachment, membrane fusion and internalization into host cells, and reduce viral replication and transcription processes ( Amini et al, 2022 ).…”

“…Antiviral activity is also shown by Artemisia annua which is one of the ingredients of Reduning Injection. Artemisia annua can inhibit SARS-CoV-2 attachment, membrane fusion and internalization into host cells, and reduce viral replication and transcription processes (Amini et al, 2022). Molecular docking analyses showed that the components present in Reduning Injection possess the capability to spontaneously bind to papain-like protease (PLpro), Mpro, and angiotensin-converting enzyme-2 (ACE-2).…”