Evaluating the effect of aqueous extract of the roots of native edible asparagus in Iran (<i>Asparagus officinalis</i> L) on the concentration of liver factors in male rats treated with cadmium chloride

Abstract

Abstract:Introduction: Cadmium is of the environmental pollutants and is considered as a part of the list of 126 top elements of environmental pollutants which has a long half-life in the body and is estimated at about 10 to 30 years. The use of herbal medicines because of having many antioxidants and lack of side effects is increasing in the today world to be a good alternative for chemical drugs. So the objective of the present study is to evaluate the effect of aqueous extract of the root of native edible asparagus in Iran (Asparagus officinalis L.) on the concentration of liver enzymes in male rats exposed to cadmium chloride.Method: 72 male rats were accidentally divided into the control, sham and test groups (100 mg/kg asparagus extract, 200 mg/kg asparagus extract, 400 mg/kg asparagus extract, 5 mg/kg cadmium chloride, cadmium chloride and 100 mg/kg asparagus extract, cadmium chloride and Abstract:Introduction: Cadmium is of the environmental pollutants and is considered as a part of the list of 126 top elements of environmental pollutants which has a long half-life in the body and is estimated at about 10 to 30 years. The use of herbal medicines because of having many antioxidants and lack of side effects is increasing in the today world to be a good alternative for chemical drugs. So the objective of the present study is to evaluate the effect of aqueous extract of the root of native edible asparagus in Iran (Asparagus officinalis L.) on the concentration of liver enzymes in male rats exposed to cadmium chloride. EVALUATING THE EFFECT OF AQUEOUS EXTRACT OF THE ROOTS OF NATIVE EDIBLE ASPARAGUS IN IRAN (ASPARAGUS OFFICINALIS L) ON THE CONCENTRATION OF LIVER FACTORS IN MALE RATS TREATED Abstract:Introduction: Cadmium is of the environmental pollutants and is considered as a part of the list of 126 top elements of environmental pollutants which has a long half-life in the body and is estimated at about 10 to 30 years. The use of herbal medicines because of having many antioxidants and lack of side effects is increasing in the today world to be a good alternative for chemical drugs. So the objective of the present study is to evaluate the effect of aqueous extract of the root of native edible asparagus in Iran (Asparagus officinalis L.) on the concentration of liver enzymes in male rats exposed to cadmium chloride.Method: 72 male rats were accidentally divided into the control, sham and test groups (100 mg/kg asparagus extract, 200 mg/kg asparagus extract, 400 mg/kg asparagus extract, 5 mg/kg cadmium chloride, cadmium chloride and 100 mg/kg asparagus extract, cadmium chloride and H .A. Abedi et al. J Fundam Appl Sci. 2016, 8(4S), 2008-2022 200 mg/kg asparagus extract, cadmium chloride and 400 mg/kg asparagus extract). All injections were performed by gavage for 28 consecutive days. One-Way ANOVA and Duncan at the significance level of 5% were used for statistical analysis.Results: Cadmium chloride increased the averages of serum ALT, AST, ALP and bilirubin significantly and decreased the averages of se...