Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered polycaprolactone/β-tricalcium phosphate materials

Doyle, Heather; Lohfeld, Stefan; McHugh, Peter E.

doi:10.1016/j.medengphy.2015.05.009

Cited by 41 publications

(23 citation statements)

References 49 publications

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“…It has been reported that the total degradation of PCL homopolymer, depending on initial molecular weight, takes between 1 and 4 years, period of time that hinders the use of PCL at short-and mid-term applications concerning BTE [27]. Up to date, PCL degradation time was decreased either by copolymerization or mixture with other lactones, polylactic acid and polyglycolic acid or by compounding of PCL with particles like hydroxyapatite, silicates and β-TCP (Tricalcium Phosphate) [27][28][29][30]. Although the latter technique have been already reported, the action mechanism of compounded particles on PCL degradation rate remains uncertain…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Controlled degradability of PCL-ZnO nanofibrous scaffolds for bone tissue engineering and their antibacterial activity

Felice

Sánchez

Socci

et al. 2018

Materials Science and Engineering: C

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Up to date, tissue regeneration of large bone defects is a clinical challenge under exhaustive study. Nowadays, the most common clinical solutions concerning bone regeneration involve systems based on human or bovine tissues, which suffer from drawbacks like antigenicity, complex processing, low osteoinductivity, rapid resorption and minimal acceleration of tissue regeneration. This work thus addresses the development of nanofibrous synthetic scaffolds of polycaprolactone (PCL)-a long-term degradation polyester-compounded with hydroxyapatite (HA) and variable concentrations of ZnO as alternative solutions for accelerated bone tissue regeneration in applications requiring mid-and long-term resorption. In vitro cell response of human fetal osteoblasts as well as antibacterial activity against Staphylococcus aureus of PCL:HA:ZnO and PCL:ZnO scaffolds were here evaluated. Furthermore, the effect of ZnO nanostructures at different concentrations on in vitro degradation of PCL electrospun scaffolds was analyzed. The results proved that higher concentrations ZnO may induce early mineralization, as indicated by high alkaline phosphatase activity levels, cell proliferation assays and positive Alizarin-RedS stained calcium deposits. Moreover, all PCL:ZnO scaffolds particularly showed antibacterial activity against S. aureus which may be attributed to release of Zn 2+ ions. Additionally, results here obtained showed a variable PCL degradation rate as a function of ZnO concentration. Therefore, this work suggests that our PCL:ZnO scaffolds may be promising and competitive short-, mid-and long-term resorption systems against current clinical solutions for bone tissue regeneration.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Controlled degradability of PCL-ZnO nanofibrous scaffolds for bone tissue engineering and their antibacterial activity

Felice

Sánchez

Socci

et al. 2018

Materials Science and Engineering: C

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“…The elastic modulus of the PCL/β-TCP scaffold materials after an equivalent of 14 weeks simulated ageing, evaluated in a previous study [31], was 37.43% of the original value, therefore a value of degraded scaffold elastic modulus can be approximated as 93.71 MPa.…”

Section: Elastic Property Assignmentmentioning

confidence: 93%

Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal

Doyle

Lohfeld

Dürselen

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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“…Tuning parameters include laser power, powder size, and the presence of additives. Among these additives, bio-ceramics such as tricalcium phosphate (β-TCP) [36,[88][89][90] and hydroxyapatite (HA) [91][92][93] have been most commonly studied. These composites allow stiffness tuning, including the incorporation of stiffness gradients [94].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered polycaprolactone/β-tricalcium phosphate materials

Cited by 41 publications

References 49 publications

Controlled degradability of PCL-ZnO nanofibrous scaffolds for bone tissue engineering and their antibacterial activity

Controlled degradability of PCL-ZnO nanofibrous scaffolds for bone tissue engineering and their antibacterial activity

Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

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